{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ongtanasup T"],"funding":["Walailak University","New Strategic Research (P2P) project, Walailak University, Thailand","Walailak University, Thailand","FCT/MEC (PIDDAC)"],"pagination":["1835"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9318486"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(14)"],"pubmed_abstract":["PCSK9 is a promising target for developing novel cholesterol-lowering drugs. We developed a recipe that combined molecular docking, GC-MS/MS, and real-time PCR to identify potential PCSK9 inhibitors for herb ratio determination. Three herbs, <i>Carthamus tinctorius</i>, <i>Coscinium fenestratum</i>, and <i>Zingiber officinale,</i> were used in this study. This work aimed to evaluate cholesterol-lowering through a PCSK9 inhibitory mechanism of these three herbs for defining a suitable ratio. Chemical constituents were identified using GC-MS/MS. The PCSK9 inhibitory potential of the compounds was determined using molecular docking, real-time PCR, and Oil red O staining. It has been shown that most of the active compounds of <i>C. fenestratum</i> and <i>Z. officinale</i> inhibit PCSK9 when ex"],"journal":["Plants (Basel, Switzerland)"],"pubmed_title":["The Cholesterol-Modulating Effect of the New Herbal Medicinal Recipe from Yellow Vine (<i>Coscinium fenestratum</i> (Goetgh.)), Ginger (<i>Zingiber officinale</i> Roscoe.), and Safflower (<i>Carthamus tinctorius</i> L.) on Suppressing PCSK9 Expression to Upregulate LDLR Expression in HepG2 Cells."],"pmcid":["PMC9318486"],"funding_grant_id":["UIDP/50011/2020","LA/P/0006/2020","WU-IRG-65-013","UIDB/50011/2020"],"pubmed_authors":["Nissapatorn V","Jampa O","Pereira ML","Wilairatana P","Wanmasae S","Eawsakul K","Prommee N","Limcharoen T","Paul AK","Ongtanasup T","Nasongkla N"],"additional_accession":[]},"is_claimable":false,"name":"The Cholesterol-Modulating Effect of the New Herbal Medicinal Recipe from Yellow Vine (<i>Coscinium fenestratum</i> (Goetgh.)), Ginger (<i>Zingiber officinale</i> Roscoe.), and Safflower (<i>Carthamus tinctorius</i> L.) on Suppressing PCSK9 Expression to Upregulate LDLR Expression in HepG2 Cells.","description":"PCSK9 is a promising target for developing novel cholesterol-lowering drugs. We developed a recipe that combined molecular docking, GC-MS/MS, and real-time PCR to identify potential PCSK9 inhibitors for herb ratio determination. Three herbs, <i>Carthamus tinctorius</i>, <i>Coscinium fenestratum</i>, and <i>Zingiber officinale,</i> were used in this study. This work aimed to evaluate cholesterol-lowering through a PCSK9 inhibitory mechanism of these three herbs for defining a suitable ratio. Chemical constituents were identified using GC-MS/MS. The PCSK9 inhibitory potential of the compounds was determined using molecular docking, real-time PCR, and Oil red O staining. It has been shown that most of the active compounds of <i>C. fenestratum</i> and <i>Z. officinale</i> inhibit PCSK9 when ex","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-05-10T03:19:56.021Z","creation":"2022-08-06T14:41:41.478Z"},"accession":"S-EPMC9318486","cross_references":{"pubmed":["35890469"],"doi":["10.3390/plants11141835"]}}