{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Siddiqa A"],"funding":["China Postdoctoral Science Foundation Fund"],"pagination":["841"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9319355"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(7)"],"pubmed_abstract":["<i>N</i>-(4-bromophenyl)furan-2-carboxamide (<b>3</b>) was synthesized by the reaction furan-2-carbonyl chloride (<b>1</b>) and 4-bromoaniline (<b>2</b>) in the presence of Et<sub>3</sub>N in excellent yields of 94%. The carboxamide (<b>3</b>) was arylated by employing triphenylphosphine palladium as a catalyst and K<sub>3</sub>PO<sub>4</sub> as a base to afford <i>N</i>-(4-bromophenyl)furan-2-carboxamide analogues (<b>5a-i</b>) in moderate to good yields (43-83%). Furthermore, we investigated the in vitro anti-bacterial activities of the respective compounds against clinically isolated drug-resistant bacteria <i>A. baumannii</i>, <i>K. pneumoniae</i>, <i>E. cloacae</i> and <i>S. aureus</i>. The molecule (<b>3</b>) was found to be the most effective activity against these bacteria, particu"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["Synthesis of Functionalized <i>N</i>-(4-Bromophenyl)furan-2-carboxamides via Suzuki-Miyaura Cross-Coupling: Anti-Bacterial Activities against Clinically Isolated Drug Resistant <i>A. baumannii</i>, <i>K. pneumoniae</i>, <i>E. cloacae</i> and MRSA and Its Validation via a Computational Approach."],"pmcid":["PMC9319355"],"funding_grant_id":["ZC304021910"],"pubmed_authors":["Mahmood S","Imran M","Ashraf GA","Zubair M","Bilal M","Ahmad G","Rasool N","Qamar MU","Khalid A","Siddiqa A"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of Functionalized <i>N</i>-(4-Bromophenyl)furan-2-carboxamides via Suzuki-Miyaura Cross-Coupling: Anti-Bacterial Activities against Clinically Isolated Drug Resistant <i>A. baumannii</i>, <i>K. pneumoniae</i>, <i>E. cloacae</i> and MRSA and Its Validation via a Computational Approach.","description":"<i>N</i>-(4-bromophenyl)furan-2-carboxamide (<b>3</b>) was synthesized by the reaction furan-2-carbonyl chloride (<b>1</b>) and 4-bromoaniline (<b>2</b>) in the presence of Et<sub>3</sub>N in excellent yields of 94%. The carboxamide (<b>3</b>) was arylated by employing triphenylphosphine palladium as a catalyst and K<sub>3</sub>PO<sub>4</sub> as a base to afford <i>N</i>-(4-bromophenyl)furan-2-carboxamide analogues (<b>5a-i</b>) in moderate to good yields (43-83%). Furthermore, we investigated the in vitro anti-bacterial activities of the respective compounds against clinically isolated drug-resistant bacteria <i>A. baumannii</i>, <i>K. pneumoniae</i>, <i>E. cloacae</i> and <i>S. aureus</i>. The molecule (<b>3</b>) was found to be the most effective activity against these bacteria, particu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-04-08T12:11:55.18Z","creation":"2022-08-06T14:59:30.051Z"},"accession":"S-EPMC9319355","cross_references":{"pubmed":["35890140"],"doi":["10.3390/ph15070841"]}}