{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Prendecki M"],"funding":["Medical Research Council Canada","Kidney Research UK","European Research Council","Medical Research Council","UK MRC"],"pagination":["300-313"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9322550"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["257(3)"],"pubmed_abstract":["P2RX7, an ionotropic receptor for extracellular adenosine triphosphate (ATP), is expressed on immune cells, including macrophages, monocytes, and dendritic cells and is upregulated on nonimmune cells following injury. P2RX7 plays a role in many biological processes, including production of proinflammatory cytokines such as interleukin (IL)-1β via the canonical inflammasome pathway. P2RX7 has been shown to be important in inflammation and fibrosis and may also play a role in autoimmunity. We have developed and phenotyped a novel P2RX7 knockout (KO) inbred rat strain and, taking advantage of the human-resembling unique histopathological features of rat models of glomerulonephritis, we induced three models of disease: nephrotoxic nephritis, experimental autoimmune glomerulonephritis, and expe"],"journal":["The Journal of pathology"],"pubmed_title":["Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways."],"pmcid":["PMC9322550"],"funding_grant_id":["RP9/2013","ERC‐2010‐AdG_20100317","MR/M004716/1","MC_U120061454","MR/N01121X/1","MR/M018733/1"],"pubmed_authors":["Turner-Stokes T","Unwin R","Aitman TJ","Tam FW","Woollard KJ","Pusey CD","McAdoo SP","Garcia-Diaz A","Prendecki M","Orriss I","Cook HT","Behmoaras J"],"additional_accession":[]},"is_claimable":false,"name":"Glomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways.","description":"P2RX7, an ionotropic receptor for extracellular adenosine triphosphate (ATP), is expressed on immune cells, including macrophages, monocytes, and dendritic cells and is upregulated on nonimmune cells following injury. P2RX7 plays a role in many biological processes, including production of proinflammatory cytokines such as interleukin (IL)-1β via the canonical inflammasome pathway. P2RX7 has been shown to be important in inflammation and fibrosis and may also play a role in autoimmunity. We have developed and phenotyped a novel P2RX7 knockout (KO) inbred rat strain and, taking advantage of the human-resembling unique histopathological features of rat models of glomerulonephritis, we induced three models of disease: nephrotoxic nephritis, experimental autoimmune glomerulonephritis, and expe","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-05-27T11:48:56.232Z","creation":"2024-11-14T17:52:23.815Z"},"accession":"S-EPMC9322550","cross_references":{"pubmed":["35239186"],"doi":["10.1002/path.5890"]}}