biostudies-literaturePrendecki MMedical Research Council CanadaKidney Research UKEuropean Research CouncilMedical Research CouncilUK MRC300-313https://www.ebi.ac.uk/biostudies/studies/S-EPMC9322550biostudies-literatureUnknown257(3)P2RX7, an ionotropic receptor for extracellular adenosine triphosphate (ATP), is expressed on immune cells, including macrophages, monocytes, and dendritic cells and is upregulated on nonimmune cells following injury. P2RX7 plays a role in many biological processes, including production of proinflammatory cytokines such as interleukin (IL)-1β via the canonical inflammasome pathway. P2RX7 has been shown to be important in inflammation and fibrosis and may also play a role in autoimmunity. We have developed and phenotyped a novel P2RX7 knockout (KO) inbred rat strain and, taking advantage of the human-resembling unique histopathological features of rat models of glomerulonephritis, we induced three models of disease: nephrotoxic nephritis, experimental autoimmune glomerulonephritis, and expeThe Journal of pathologyGlomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways.PMC9322550RP9/2013ERC‐2010‐AdG_20100317MR/M004716/1MC_U120061454MR/N01121X/1MR/M018733/1Turner-Stokes TUnwin RAitman TJTam FWWoollard KJPusey CDMcAdoo SPGarcia-Diaz APrendecki MOrriss ICook HTBehmoaras JfalseGlomerulonephritis and autoimmune vasculitis are independent of P2RX7 but may depend on alternative inflammasome pathways.P2RX7, an ionotropic receptor for extracellular adenosine triphosphate (ATP), is expressed on immune cells, including macrophages, monocytes, and dendritic cells and is upregulated on nonimmune cells following injury. P2RX7 plays a role in many biological processes, including production of proinflammatory cytokines such as interleukin (IL)-1β via the canonical inflammasome pathway. P2RX7 has been shown to be important in inflammation and fibrosis and may also play a role in autoimmunity. We have developed and phenotyped a novel P2RX7 knockout (KO) inbred rat strain and, taking advantage of the human-resembling unique histopathological features of rat models of glomerulonephritis, we induced three models of disease: nephrotoxic nephritis, experimental autoimmune glomerulonephritis, and expe2022-01-01T00:00:00Z2022 Jul2026-05-27T11:48:56.232Z2024-11-14T17:52:23.815ZS-EPMC93225503523918610.1002/path.5890