biostudies-literatureCuong NMJSPS RONPAKU Ph.D. program for FYVietnam National Foundation for Science and Technology Development (NAFOSTED)Vietnam National Foundation for Science and Technology Development4505https://www.ebi.ac.uk/biostudies/studies/S-EPMC9324545biostudies-literatureUnknown27(14)Hypertension is a risk factor for cardiovascular diseases, which are the main cause of morbidity and mortality in the world. In the search for new molecules capable of targeting K_Ca1.1 and Ca_V1.2 channels, the expression of which is altered in hypertension, the in vitro vascular effects of a series of flavonoids extracted from the heartwoods, roots, and leaves of <i>Dalbergia tonkinensis</i> Prain, widely used in traditional medicine, were assessed. Rat aorta rings, tail artery myocytes, and docking and molecular dynamics simulations were used to analyse their effect on these channels. Formononetin, orobol, pinocembrin, and biochanin A showed a marked myorelaxant activity, particularly in rings stimulated by moderate rather than high KCl concentrations. Ba<sup>2+</supMolecules (Basel, Switzerland)Vietnamese <i>Dalbergia tonkinensis</i>: A Promising Source of Mono- and Bifunctional Vasodilators.PMC93245452017104.01-2015.49Fusi FSon NTSaponara SVigni GCuong NMNhan NTFukuyama YTrezza AAhmed AGianibbi BSpiga OfalseVietnamese <i>Dalbergia tonkinensis</i>: A Promising Source of Mono- and Bifunctional Vasodilators.Hypertension is a risk factor for cardiovascular diseases, which are the main cause of morbidity and mortality in the world. In the search for new molecules capable of targeting K_Ca1.1 and Ca_V1.2 channels, the expression of which is altered in hypertension, the in vitro vascular effects of a series of flavonoids extracted from the heartwoods, roots, and leaves of <i>Dalbergia tonkinensis</i> Prain, widely used in traditional medicine, were assessed. Rat aorta rings, tail artery myocytes, and docking and molecular dynamics simulations were used to analyse their effect on these channels. Formononetin, orobol, pinocembrin, and biochanin A showed a marked myorelaxant activity, particularly in rings stimulated by moderate rather than high KCl concentrations. Ba<sup>2+</sup2022-01-01T00:00:00Z2022 Jul2025-04-25T16:52:57.465Z2022-08-06T22:42:24.789ZS-EPMC93245453588938610.3390/molecules27144505