{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Del Grosso E"],"funding":["Associazione Italiana per la Ricerca sul Cancro","Deutsche Forschungsgemeinschaft","European Research Council","H2020 Marie Skłodowska-Curie Actions"],"pagination":["e202201929"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9324813"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(23)"],"pubmed_abstract":["Here we show a general approach to achieve dissipative control over toehold-mediated strand-displacement, the most widely employed reaction in the field of DNA nanotechnology. The approach relies on rationally re-engineering the classic strand displacement reaction such that the high-energy invader strand (fuel) is converted into a low-energy waste product through an energy-dissipating reaction allowing the spontaneous return to the original state over time. We show that such dissipative control over the toehold-mediated strand displacement process is reversible (up to 10 cycles), highly controllable and enables unique temporal activation of DNA systems. We show here two possible applications of this strategy: the transient labelling of DNA structures and the additional temporal control of cascade reactions."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Dissipative Control over the Toehold-Mediated DNA Strand Displacement Reaction."],"pmcid":["PMC9324813"],"funding_grant_id":["SE 1646/9-1","819160","896962","21965"],"pubmed_authors":["Seidel R","Irmisch P","Ricci F","Prins LJ","Del Grosso E","Gentile S"],"additional_accession":[]},"is_claimable":false,"name":"Dissipative Control over the Toehold-Mediated DNA Strand Displacement Reaction.","description":"Here we show a general approach to achieve dissipative control over toehold-mediated strand-displacement, the most widely employed reaction in the field of DNA nanotechnology. The approach relies on rationally re-engineering the classic strand displacement reaction such that the high-energy invader strand (fuel) is converted into a low-energy waste product through an energy-dissipating reaction allowing the spontaneous return to the original state over time. We show that such dissipative control over the toehold-mediated strand displacement process is reversible (up to 10 cycles), highly controllable and enables unique temporal activation of DNA systems. We show here two possible applications of this strategy: the transient labelling of DNA structures and the additional temporal control of cascade reactions.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-18T15:36:45.367Z","creation":"2025-04-07T02:20:18.978Z"},"accession":"S-EPMC9324813","cross_references":{"pubmed":["35315568"],"doi":["10.1002/anie.202201929"]}}