biostudies-literatureMellis RNational Institute for Health Research (NIHR)783-795https://www.ebi.ac.uk/biostudies/studies/S-EPMC9324936biostudies-literatureUnknown42(6)<h4>Objectives</h4>Prenatal exome sequencing (pES) for the diagnosis of fetal abnormalities is being introduced more widely in clinical practice. Here we explore parents' and professionals' views and experiences of pES, to identify perceived benefits, concerns, and support needs.<h4>Methods</h4>Semi-structured interviews were conducted with 11 parents and 20 health professionals (fetal medicine and clinical genetics) with experience of rapid pES prior to implementation in the English National Health Service. Interviews were transcribed verbatim and analysed thematically.<h4>Results</h4>Parents and professionals were largely positive about pES, emphasising clinical and psychosocial benefits of a timely, definitive diagnosis in pregnancy. Concerns included parental anxiety related to the timPrenatal diagnosisImplementing a rapid fetal exome sequencing service: What do parents and health professionals think?PMC9324936NIHR-INF-0957Shannon NDempsey EPandya PTapon DHill MMellis RChitty LSfalseImplementing a rapid fetal exome sequencing service: What do parents and health professionals think?<h4>Objectives</h4>Prenatal exome sequencing (pES) for the diagnosis of fetal abnormalities is being introduced more widely in clinical practice. Here we explore parents' and professionals' views and experiences of pES, to identify perceived benefits, concerns, and support needs.<h4>Methods</h4>Semi-structured interviews were conducted with 11 parents and 20 health professionals (fetal medicine and clinical genetics) with experience of rapid pES prior to implementation in the English National Health Service. Interviews were transcribed verbatim and analysed thematically.<h4>Results</h4>Parents and professionals were largely positive about pES, emphasising clinical and psychosocial benefits of a timely, definitive diagnosis in pregnancy. Concerns included parental anxiety related to the tim2022-01-01T00:00:00Z2022 May2025-04-19T11:19:15.245Z2025-04-19T11:19:15.245ZS-EPMC93249363538398110.1002/pd.6140