{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Laurent Q"],"funding":["Swiss National Science Foundation","National Centre of Competence in Research (NCCR), Chemical Biology","National Centre of Competence in Research (NCCR), Molecular Systems Engineering","Université de Genève"],"pagination":["e202200785"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9324982"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(33)"],"pubmed_abstract":["A model system is introduced as a general tool to elaborate on orthogonal templation of dynamic covalent ring-opening polymerization (ODC-TROP). The tool consists of 3<sub>10</sub> helical peptides as unprecedented templates and semicarbazones as orthogonal dynamic covalent linkers. With difficult-to-control 1,2-dithiolanes, ODC-TROP on the level of short model oligomers occurs with high templation efficiency, increasing and diminishing upon helix stabilization and denaturation, respectively. Further, an anti-templated conjugate with mispositioned monomers gave reduced templation upon helix twisting. Even with the \"unpolymerizable\" 1,2-diselenolanes, initial studies already afford mild templation efficiency. These proof-of-principle results promise that the here introduced tool, recyclable and enabling late-stage side chain modification, will be useful to realize ODC-TROP of intractable or unknown cyclic dynamic covalent monomers for dynamer materials as well as cellular uptake and signaling applications."],"journal":["Chemistry (Weinheim an der Bergstrasse, Germany)"],"pubmed_title":["An Orthogonal Dynamic Covalent Chemistry Tool for Ring-Opening Polymerization of Cyclic Oligochalcogenides on Detachable Helical Peptide Templates."],"pmcid":["PMC9324982"],"funding_grant_id":["200020_204175"],"pubmed_authors":["Matile S","Laurent Q","Sakai N"],"additional_accession":[]},"is_claimable":false,"name":"An Orthogonal Dynamic Covalent Chemistry Tool for Ring-Opening Polymerization of Cyclic Oligochalcogenides on Detachable Helical Peptide Templates.","description":"A model system is introduced as a general tool to elaborate on orthogonal templation of dynamic covalent ring-opening polymerization (ODC-TROP). The tool consists of 3<sub>10</sub> helical peptides as unprecedented templates and semicarbazones as orthogonal dynamic covalent linkers. With difficult-to-control 1,2-dithiolanes, ODC-TROP on the level of short model oligomers occurs with high templation efficiency, increasing and diminishing upon helix stabilization and denaturation, respectively. Further, an anti-templated conjugate with mispositioned monomers gave reduced templation upon helix twisting. Even with the \"unpolymerizable\" 1,2-diselenolanes, initial studies already afford mild templation efficiency. These proof-of-principle results promise that the here introduced tool, recyclable and enabling late-stage side chain modification, will be useful to realize ODC-TROP of intractable or unknown cyclic dynamic covalent monomers for dynamer materials as well as cellular uptake and signaling applications.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-26T16:13:32.845Z","creation":"2025-04-06T15:10:28.772Z"},"accession":"S-EPMC9324982","cross_references":{"pubmed":["35416345"],"doi":["10.1002/chem.202200785"]}}