{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(6)"],"submitter":["Jalian HR"],"funding":["Allergan"],"pubmed_abstract":["<h4>Background</h4>Submental fat (SMF) detracts from facial aesthetics and negatively impacts self-image.<h4>Aims</h4>To evaluate safety, effectiveness, and satisfaction of cryolipolysis and ATX-101 used sequentially to reduce SMF.<h4>Methods</h4>A prospective, open-label, interventional, single-site study enrolling 22- to 65-year-old participants rated as Grade 4 (extreme) on the Clinician-Rated SMF Rating Scale (CR-SMFRS). Co-primary effectiveness endpoints were proportions of participants with ≥1-grade and ≥2-grade improvement on CR-SMFRS at 12 weeks post final treatment. Additional assessments included ultrasound measurement of fat thickness and Subject Self-Rating Scale (SSRS) scores at 12 weeks post final treatment. Safety was assessed throughout the study.<h4>Results</h4>Of 16 enrol"],"journal":["Journal of cosmetic dermatology"],"pagination":["2437-2444"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9325515"],"repository":["biostudies-literature"],"pubmed_title":["Submental fat reduction using sequential treatment approach with cryolipolysis and ATX-101."],"pmcid":["PMC9325515"],"pubmed_authors":["Bowen B","Fitzgerald R","Jalian HR","Gamio S"],"additional_accession":[]},"is_claimable":false,"name":"Submental fat reduction using sequential treatment approach with cryolipolysis and ATX-101.","description":"<h4>Background</h4>Submental fat (SMF) detracts from facial aesthetics and negatively impacts self-image.<h4>Aims</h4>To evaluate safety, effectiveness, and satisfaction of cryolipolysis and ATX-101 used sequentially to reduce SMF.<h4>Methods</h4>A prospective, open-label, interventional, single-site study enrolling 22- to 65-year-old participants rated as Grade 4 (extreme) on the Clinician-Rated SMF Rating Scale (CR-SMFRS). Co-primary effectiveness endpoints were proportions of participants with ≥1-grade and ≥2-grade improvement on CR-SMFRS at 12 weeks post final treatment. Additional assessments included ultrasound measurement of fat thickness and Subject Self-Rating Scale (SSRS) scores at 12 weeks post final treatment. Safety was assessed throughout the study.<h4>Results</h4>Of 16 enrol","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-18T15:36:52.205Z","creation":"2025-04-07T02:20:29.318Z"},"accession":"S-EPMC9325515","cross_references":{"pubmed":["35278262"],"doi":["10.1111/jocd.14909"]}}