{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["94(1125)"],"submitter":["Sahin H"],"pubmed_abstract":["<h4>Objective</h4>To assess the value of non-contrast MRI features for characterisation of uterine leiomyosarcoma (LMS) and differentiation from atypical benign leiomyomas.<h4>Methods</h4>This study included 57 atypical leiomyomas and 16 LMS which were referred pre-operatively for management review to the specialist gynaeoncology multidisciplinary team meeting. Non-contrast MRIs were retrospectively reviewed by five independent readers (three senior, two junior) and a 5-level Likert score (1-low/5-high) was assigned to each mass for likelihood of LMS. Evaluation of qualitative and quantitative MRI features was done using uni- and multivariable regression analysis. Inter-reader reliability for the assessment of MRI features was calculated by using Cohen's κ values.<h4>Results</h4>In the univariate analysis, interruption of the endometrial interface and irregular tumour shape had the highest odds ratios (ORs) (64.00, <i>p</i> < 0.001 and 12.00, <i>p</i> = 0.002, respectively) for prediction of LMS. Likert score of the mass was significant in prediction (OR, 3.14; <i>p</i> < 0.001) with excellent reliability between readers (ICC 0.86; 95% CI, 0.76-0.92). The post-menopausal status, interruption of endometrial interface and thickened endometrial stripe were the most predictive independent variables in multivariable estimation of the risk of leiomyosarcoma with an accuracy of 0.88 (95%CI, 0.78-0.94).<h4>Conclusion</h4>At any level of expertise as a radiologist reader, the loss of the normal endometrial stripe (either thickened or not seen) in a post-menopausal patient with a myometrial mass was highly likely to be LMS.<h4>Advances in knowledge</h4>This study demonstrates the potential utility of non-contrast MRI features in characterisation of LMS over atypical leiomyomas, and therefore influence on optimal management of these cases."],"journal":["The British journal of radiology"],"pagination":["20210115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9327768"],"repository":["biostudies-literature"],"pubmed_title":["Diagnostic interpretation of non-contrast qualitative MR imaging features for characterisation of uterine leiomyosarcoma."],"pmcid":["PMC9327768"],"pubmed_authors":["Sahin H","Carmisciano L","Addley H","Shakur A","Caglic I","Zawaideh JP","Bruining A","Freeman S","Jimenez-Linan M","Smith J"],"additional_accession":[]},"is_claimable":false,"name":"Diagnostic interpretation of non-contrast qualitative MR imaging features for characterisation of uterine leiomyosarcoma.","description":"<h4>Objective</h4>To assess the value of non-contrast MRI features for characterisation of uterine leiomyosarcoma (LMS) and differentiation from atypical benign leiomyomas.<h4>Methods</h4>This study included 57 atypical leiomyomas and 16 LMS which were referred pre-operatively for management review to the specialist gynaeoncology multidisciplinary team meeting. Non-contrast MRIs were retrospectively reviewed by five independent readers (three senior, two junior) and a 5-level Likert score (1-low/5-high) was assigned to each mass for likelihood of LMS. Evaluation of qualitative and quantitative MRI features was done using uni- and multivariable regression analysis. Inter-reader reliability for the assessment of MRI features was calculated by using Cohen's κ values.<h4>Results</h4>In the univariate analysis, interruption of the endometrial interface and irregular tumour shape had the highest odds ratios (ORs) (64.00, <i>p</i> < 0.001 and 12.00, <i>p</i> = 0.002, respectively) for prediction of LMS. Likert score of the mass was significant in prediction (OR, 3.14; <i>p</i> < 0.001) with excellent reliability between readers (ICC 0.86; 95% CI, 0.76-0.92). The post-menopausal status, interruption of endometrial interface and thickened endometrial stripe were the most predictive independent variables in multivariable estimation of the risk of leiomyosarcoma with an accuracy of 0.88 (95%CI, 0.78-0.94).<h4>Conclusion</h4>At any level of expertise as a radiologist reader, the loss of the normal endometrial stripe (either thickened or not seen) in a post-menopausal patient with a myometrial mass was highly likely to be LMS.<h4>Advances in knowledge</h4>This study demonstrates the potential utility of non-contrast MRI features in characterisation of LMS over atypical leiomyomas, and therefore influence on optimal management of these cases.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-05-31T22:50:47.537Z","creation":"2025-05-31T22:50:47.537Z"},"accession":"S-EPMC9327768","cross_references":{"pubmed":["34111973"],"doi":["10.1259/bjr.20210115"]}}