biostudies-literatureUnknown59(6)van Limburg Stirum EVJ<h4>Objective</h4>To evaluate the effect of cervical pessary, as a strategy to prevent preterm birth (PTB), on the outcome of subsequent pregnancy and maternal quality of life 4 years after the index twin pregnancy.<h4>Methods</h4>Between 2009 and 2012, the ProTWIN trial randomized women with a multiple pregnancy to pessary use vs standard care for the prevention of PTB. The trial showed no benefit in unselected women with a twin pregnancy, but showed a 60% reduction in poor perinatal outcomes in favor of the pessary group in the subgroup of women with a mid-trimester short cervix (cervical length < 38 mm). All women were invited to participate in a follow-up study 4 years after their participation in the ProTWIN trial. In this follow-up study, maternal quality of life was assessed using tUltrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology771-777https://www.ebi.ac.uk/biostudies/studies/S-EPMC9328140biostudies-literatureConsequences of cervical pessary for subsequent pregnancy: follow-up of randomized clinical trial (ProTWIN).PMC9328140van 't Hooft JOudijk MAMol BWJvan Limburg Stirum EVJSimons NEde Boer MAZegveld SJPajkrt EfalseConsequences of cervical pessary for subsequent pregnancy: follow-up of randomized clinical trial (ProTWIN).<h4>Objective</h4>To evaluate the effect of cervical pessary, as a strategy to prevent preterm birth (PTB), on the outcome of subsequent pregnancy and maternal quality of life 4 years after the index twin pregnancy.<h4>Methods</h4>Between 2009 and 2012, the ProTWIN trial randomized women with a multiple pregnancy to pessary use vs standard care for the prevention of PTB. The trial showed no benefit in unselected women with a twin pregnancy, but showed a 60% reduction in poor perinatal outcomes in favor of the pessary group in the subgroup of women with a mid-trimester short cervix (cervical length < 38 mm). All women were invited to participate in a follow-up study 4 years after their participation in the ProTWIN trial. In this follow-up study, maternal quality of life was assessed using t2022-01-01T00:00:00Z2022 Jun2025-04-18T18:05:50.969Z2025-04-07T05:43:20.271ZS-EPMC93281403482616610.1002/uog.24821