{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(10)"],"submitter":["Lan M"],"pubmed_abstract":["Myocardial ischemia reperfusion (IR) injury is closely related to the overwhelming inflammation in the myocardium. Herein, cardiomyocyte-targeted nanotherapeutics were developed for the reactive oxygen species (ROS)-ultrasensitive co-delivery of dexamethasone (Dex) and RAGE small interfering RNA (siRAGE) to attenuate myocardial inflammation. PPTP, a ROS-degradable polycation based on PGE<sub>2</sub>-modified, PEGylated, ditellurium-crosslinked polyethylenimine (PEI) was developed to surface-decorate the Dex-encapsulated mesoporous silica nanoparticles (MSNs), which simultaneously condensed siRAGE and gated the MSNs to prevent the Dex pre-leakage. Upon intravenous injection to IR-injured rats, the nanotherapeutics could be efficiently transported into the inflamed cardiomyocytes via PGE<sub"],"journal":["Nano research"],"pagination":["9125-9134"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9328183"],"repository":["biostudies-literature"],"pubmed_title":["Cardiomyocyte-targeted anti-inflammatory nanotherapeutics against myocardial ischemia reperfusion (IR) injury."],"pmcid":["PMC9328183"],"pubmed_authors":["Hou M","Yan J","Dang J","Deng Q","Lv S","Lan M","Ji Y","Yin M","Zhao Z","Yin L"],"additional_accession":[]},"is_claimable":false,"name":"Cardiomyocyte-targeted anti-inflammatory nanotherapeutics against myocardial ischemia reperfusion (IR) injury.","description":"Myocardial ischemia reperfusion (IR) injury is closely related to the overwhelming inflammation in the myocardium. Herein, cardiomyocyte-targeted nanotherapeutics were developed for the reactive oxygen species (ROS)-ultrasensitive co-delivery of dexamethasone (Dex) and RAGE small interfering RNA (siRAGE) to attenuate myocardial inflammation. PPTP, a ROS-degradable polycation based on PGE<sub>2</sub>-modified, PEGylated, ditellurium-crosslinked polyethylenimine (PEI) was developed to surface-decorate the Dex-encapsulated mesoporous silica nanoparticles (MSNs), which simultaneously condensed siRAGE and gated the MSNs to prevent the Dex pre-leakage. Upon intravenous injection to IR-injured rats, the nanotherapeutics could be efficiently transported into the inflamed cardiomyocytes via PGE<sub","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T08:55:59.204Z","creation":"2025-04-05T08:55:59.204Z"},"accession":"S-EPMC9328183","cross_references":{"pubmed":["35915748"],"doi":["10.1007/s12274-022-4553-6"]}}