biostudies-literatureUnknown16(7)Omil-Lima D<h4>Introduction</h4>Limited data guide urological practice when employing prostate magnetic resonance imaging (MRI) in active surveillance (AS) protocols. To determine the ability of prostate MRI to predict pathological progression in AS patients, we correlated findings of serial MRI with results of surveillance biopsies.<h4>Methods</h4>Patients on AS with ≥2 prostate MRI and ≥2 prostate biopsies were included. Prostate Imaging-Reporting and Data System (PI-RADS) score upgrade, as assigned by experienced radiologists, was used to assess the ability of imaging to predict pathological biopsy progression. Imaging test statistics and the odds ratio of pathological progression according to MRI upgrade were calculated.<h4>Results</h4>Of 121 patients meeting criteria, 36 (30%) demonstrated MRI uCanadian Urological Association journal = Journal de l'Association des urologues du CanadaE370-E374https://www.ebi.ac.uk/biostudies/studies/S-EPMC9328855biostudies-literatureSerial prostate magnetic resonance imaging fails to predict pathological progression in patients on active surveillance.PMC9328855Kim APonsky LWeinstein IGupta KSheyn DOmil-Lima DfalseSerial prostate magnetic resonance imaging fails to predict pathological progression in patients on active surveillance.<h4>Introduction</h4>Limited data guide urological practice when employing prostate magnetic resonance imaging (MRI) in active surveillance (AS) protocols. To determine the ability of prostate MRI to predict pathological progression in AS patients, we correlated findings of serial MRI with results of surveillance biopsies.<h4>Methods</h4>Patients on AS with ≥2 prostate MRI and ≥2 prostate biopsies were included. Prostate Imaging-Reporting and Data System (PI-RADS) score upgrade, as assigned by experienced radiologists, was used to assess the ability of imaging to predict pathological biopsy progression. Imaging test statistics and the odds ratio of pathological progression according to MRI upgrade were calculated.<h4>Results</h4>Of 121 patients meeting criteria, 36 (30%) demonstrated MRI u2022-01-01T00:00:00Z2022 Jul2025-04-18T18:09:10.347Z2025-04-07T05:40:17.572ZS-EPMC93288553523093310.5489/cuaj.7541