biostudies-literatureHuang WNICHD NIH HHSNIEHS NIH HHS1435-1445https://www.ebi.ac.uk/biostudies/studies/S-EPMC9329205biostudies-literatureUnknown46(8)<h4>Background/objectives</h4>Low-level, in-utero exposure to toxic metals such as lead (Pb) and mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be obesogenic in children. To address the literature gaps on the health effects of co-exposure to low-level toxic metals and the lack of intervention strategy, we aimed to investigate the association between in-utero co-exposure to Hg, Pb, cadmium (Cd) and childhood overweight or obesity (OWO) and whether adequate maternal micronutrients (selenium (Se) and folate) can be protective.<h4>Subjects/methods</h4>This study included 1442 mother-child pairs from the Boston Birth Cohort, a predominantly urban, low-income, Black, and Hispanic population, who were enrolled at birth and followed prospectively up to age 15 yInternational journal of obesity (2005)In-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals.PMC9329205R03 ES029594R01 ES031272R21 ES011666R01 HD086013R01 HD041702R01 ES031521R21 HD066471R01 HD098232Haltmeier DXu RIgusa TWang GHou WMukherjee JSteffens AHong XHuang WBuckley JPBind EJi YWang XTina Fan ZfalseIn-utero co-exposure to toxic metals and micronutrients on childhood risk of overweight or obesity: new insight on micronutrients counteracting toxic metals.<h4>Background/objectives</h4>Low-level, in-utero exposure to toxic metals such as lead (Pb) and mercury (Hg) is widespread in the US and worldwide; and, individually, was found to be obesogenic in children. To address the literature gaps on the health effects of co-exposure to low-level toxic metals and the lack of intervention strategy, we aimed to investigate the association between in-utero co-exposure to Hg, Pb, cadmium (Cd) and childhood overweight or obesity (OWO) and whether adequate maternal micronutrients (selenium (Se) and folate) can be protective.<h4>Subjects/methods</h4>This study included 1442 mother-child pairs from the Boston Birth Cohort, a predominantly urban, low-income, Black, and Hispanic population, who were enrolled at birth and followed prospectively up to age 15 y2022-01-01T00:00:00Z2022 Aug2026-05-09T13:39:09.999Z2024-11-09T22:27:18.85ZS-EPMC93292053558996210.1038/s41366-022-01127-x