biostudies-literatureShen JNIA NIH HHSFoundation for the National Institutes of HealthNINDS NIH HHSNational Institutes of HealthChan Zuckerberg InitiativeMichael J. Fox Foundation for Parkinson&apos;s Research255-269https://www.ebi.ac.uk/biostudies/studies/S-EPMC9329215biostudies-literatureUnknown92(2)<h4>Objective</h4>Using a multi-cohort, discovery-replication-validation design, we sought new plasma biomarkers that predict which individuals with Parkinson's disease (PD) will experience cognitive decline.<h4>Methods</h4>In 108 discovery cohort PD individuals and 83 replication cohort PD individuals, we measured 940 plasma proteins on an aptamer-based platform. Using proteins associated with subsequent cognitive decline in both cohorts, we trained a logistic regression model to predict which patients with PD showed fast (> = 1 point drop/year on Montreal Cognitive Assessment [MoCA]) versus slow (< 1 point drop/year on MoCA) cognitive decline in the discovery cohort, testing it in the replication cohort. We developed alternate assays for the top 3 proteins and confirmed their ability to Annals of neurologyPlasma MIA, CRP, and Albumin Predict Cognitive Decline in Parkinson's Disease.PMC9329215U19 AG062418RO1 NS115139Biomarkers Across Neurodegenerative Diseases (BANDR01 NS115139P50 NS053488P30 AG072979Skrinak RTShen JUnger TLVan Deerlin VMTrojanowski JQWeintraub DPosavi MXie SXZack RDewey RBChen-Plotkin ASAmari NTropea TFfalsePlasma MIA, CRP, and Albumin Predict Cognitive Decline in Parkinson's Disease.<h4>Objective</h4>Using a multi-cohort, discovery-replication-validation design, we sought new plasma biomarkers that predict which individuals with Parkinson's disease (PD) will experience cognitive decline.<h4>Methods</h4>In 108 discovery cohort PD individuals and 83 replication cohort PD individuals, we measured 940 plasma proteins on an aptamer-based platform. Using proteins associated with subsequent cognitive decline in both cohorts, we trained a logistic regression model to predict which patients with PD showed fast (> = 1 point drop/year on Montreal Cognitive Assessment [MoCA]) versus slow (< 1 point drop/year on MoCA) cognitive decline in the discovery cohort, testing it in the replication cohort. We developed alternate assays for the top 3 proteins and confirmed their ability to 2022-01-01T00:00:00Z2022 Aug2026-05-05T03:10:01.393Z2025-04-04T20:28:48.201ZS-EPMC93292153559302810.1002/ana.26410