biostudies-literatureRandhawa ASNINDS NIH HHS2426-2434https://www.ebi.ac.uk/biostudies/studies/S-EPMC9329219biostudies-literatureUnknown53(8)<h4>Background</h4>To emphasize treatment speed for time-sensitive conditions, emergency medicine has developed not only the concept of the golden hour, but also the platinum half-hour. Patients with acute stroke treated within the first half-hour of onset have not been previously characterized.<h4>Methods</h4>In this cohort study, we analyzed patients enrolled in the FAST-MAG (Field Administration of Stroke Therapy-Magnesium) trial, testing paramedic prehospital start of neuroprotective agent ≤2 hours of onset. The features of all acute cerebral ischemia, and intracranial hemorrhage patients with treatment starting at ≤30 m of last known well were compared with later-treated patients.<h4>Results</h4>Among 1680 patients, 203 (12.1%) received study agents within 30 minutes of last known welStrokeBeyond the Golden Hour: Treating Acute Stroke in the Platinum 30 Minutes.PMC9329219U01 NS044364Valdes-Sueiras MRestrepo-Jimenez LConwit RHamilton SVillablanca PPariona-Vargas FGornbein JSharma LRandhawa ASSaver JLSanossian NLiebeskind DSKim-Tenser MStarkman SAvila GStratton SfalseBeyond the Golden Hour: Treating Acute Stroke in the Platinum 30 Minutes.<h4>Background</h4>To emphasize treatment speed for time-sensitive conditions, emergency medicine has developed not only the concept of the golden hour, but also the platinum half-hour. Patients with acute stroke treated within the first half-hour of onset have not been previously characterized.<h4>Methods</h4>In this cohort study, we analyzed patients enrolled in the FAST-MAG (Field Administration of Stroke Therapy-Magnesium) trial, testing paramedic prehospital start of neuroprotective agent ≤2 hours of onset. The features of all acute cerebral ischemia, and intracranial hemorrhage patients with treatment starting at ≤30 m of last known well were compared with later-treated patients.<h4>Results</h4>Among 1680 patients, 203 (12.1%) received study agents within 30 minutes of last known wel2022-01-01T00:00:00Z2022 Aug2025-04-04T20:06:55.677Z2025-04-04T20:06:55.677ZS-EPMC93292193554593910.1161/STROKEAHA.121.03699310.1161/strokeaha.121.036993