{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kolte D"],"funding":["NHLBI NIH HHS"],"pagination":["934-944"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9330296"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(9)"],"pubmed_abstract":["<h4>Importance</h4>In patients with severe aortic stenosis and left ventricular ejection fraction (LVEF) less than 50%, early LVEF improvement after transcatheter aortic valve replacement (TAVR) is associated with improved 1-year mortality; however, its association with long-term clinical outcomes is not known.<h4>Objective</h4>To examine the association between early LVEF improvement after TAVR and 5-year outcomes.<h4>Design, setting, and participants</h4>This cohort study analyzed patients enrolled in the Placement of Aortic Transcatheter Valves (PARTNER) 1, 2, and S3 trials and registries between July 2007 and April 2015. High- and intermediate-risk patients with baseline LVEF less than 50% who underwent transfemoral TAVR were included in the current study. Data were analyzed from Augus"],"journal":["JAMA cardiology"],"pubmed_title":["Association Between Early Left Ventricular Ejection Fraction Improvement After Transcatheter Aortic Valve Replacement and 5-Year Clinical Outcomes."],"pmcid":["PMC9330296"],"funding_grant_id":["K23 HL157612"],"pubmed_authors":["Vlahakes GJ","Smith CR","Bhardwaj B","Daubert MA","Jaber W","Elmariah S","Garcia S","Inglessis I","Kodali S","Mack MJ","Pibarot P","Clavel MA","Palacios IF","Thourani VH","Passeri JJ","Lindman BR","Lu M","Douglas PS","Kolte D","Leon MB","Cohen DJ","Alu MC"],"additional_accession":[]},"is_claimable":false,"name":"Association Between Early Left Ventricular Ejection Fraction Improvement After Transcatheter Aortic Valve Replacement and 5-Year Clinical Outcomes.","description":"<h4>Importance</h4>In patients with severe aortic stenosis and left ventricular ejection fraction (LVEF) less than 50%, early LVEF improvement after transcatheter aortic valve replacement (TAVR) is associated with improved 1-year mortality; however, its association with long-term clinical outcomes is not known.<h4>Objective</h4>To examine the association between early LVEF improvement after TAVR and 5-year outcomes.<h4>Design, setting, and participants</h4>This cohort study analyzed patients enrolled in the Placement of Aortic Transcatheter Valves (PARTNER) 1, 2, and S3 trials and registries between July 2007 and April 2015. High- and intermediate-risk patients with baseline LVEF less than 50% who underwent transfemoral TAVR were included in the current study. Data were analyzed from Augus","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T20:07:43.25Z","creation":"2025-04-04T20:07:43.25Z"},"accession":"S-EPMC9330296","cross_references":{"pubmed":["35895046"],"doi":["10.1001/jamacardio.2022.2222"]}}