{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jain P"],"funding":["NIA NIH HHS","NIEHS NIH HHS","NHLBI NIH HHS","NCI NIH HHS"],"pagination":["e2223285"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9331104"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(7)"],"pubmed_abstract":["<h4>Importance</h4>Accelerated biological aging is associated with decreased physical capability and cognitive functioning, which are associated with increased risk of morbidity and mortality.<h4>Objective</h4>We investigated associations between epigenetic age acceleration (EAA), a biomarker associated with aging, and healthy longevity among older women.<h4>Design, setting, and participants</h4>This cohort study was a secondary analysis of participants in the Women's Health Initiative (WHI) who were eligible to survive to age 90 years by September 30, 2020. Participants were located in multiple centers. This study was restricted to women with genome-wide DNA methylation data, generated from baseline blood samples within 3 WHI ancillary studies. Median (IQR) follow-up times from baseline w"],"journal":["JAMA network open"],"pubmed_title":["Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women."],"pmcid":["PMC9331104"],"funding_grant_id":["R01 ES020836","HHSN268201300006C","T32 AG058529","HHSN268201600002C","HHSN268201600003C","U54 CA132379","HHSN268201600001C","U54 CA132384","HHSN268201600018C","HHSN268201600004C"],"pubmed_authors":["Jain P","Gallo LC","Jordahl K","LaCroix AZ","Bhatti P","Baccarelli AA","Horvath S","Justice JN","Chen B","Parada H","Alcaraz J","Whitsel EA","Hou L","Li Y","Binder AM","Stewart JD"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of Epigenetic Age Acceleration and Healthy Longevity Among Older US Women.","description":"<h4>Importance</h4>Accelerated biological aging is associated with decreased physical capability and cognitive functioning, which are associated with increased risk of morbidity and mortality.<h4>Objective</h4>We investigated associations between epigenetic age acceleration (EAA), a biomarker associated with aging, and healthy longevity among older women.<h4>Design, setting, and participants</h4>This cohort study was a secondary analysis of participants in the Women's Health Initiative (WHI) who were eligible to survive to age 90 years by September 30, 2020. Participants were located in multiple centers. This study was restricted to women with genome-wide DNA methylation data, generated from baseline blood samples within 3 WHI ancillary studies. Median (IQR) follow-up times from baseline w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-27T03:20:26.339Z","creation":"2025-04-06T18:49:47.017Z"},"accession":"S-EPMC9331104","cross_references":{"pubmed":["35895062"],"doi":["10.1001/jamanetworkopen.2022.23285"]}}