{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sasse C"],"funding":["Deutsche Forschungsgemeinschaft","Interdisciplinary Center for Clinical Research (IZKF), Universitätsklinikum Erlangen","Federal Ministry of Education and Research"],"pagination":["828"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9331382"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(8)"],"pubmed_abstract":["Interleukin (IL)-4 plays a central role in the initiation of a type 2 T helper cell (Th2) response, which leads to non-healing and progressive infections with the protozoan parasite <i>Leishmania</i> (<i>L.</i>) <i>major</i>. Here, we tested the hypothesis that type 2 innate lymphoid cells (ILC2), which promote the development of Th2 cells, form an important source of IL-4 early after intradermal or subcutaneous <i>L. major</i> infection. Lineage-marker negative CD90.2<sup>+</sup>CD127<sup>+</sup>PD1<sup>-</sup> ILC2 were readily detectable in the ear or foot skin, but hardly in the draining lymph nodes of both naïve and <i>L. major</i>-infected self-healing C57BL/6 and non-healing BALB/c mice and made up approximately 20% to 30% of all CD45<sup>+</sup>SiglecF<sup>-</sup> cells. Dermal ILC"],"journal":["Pathogens (Basel, Switzerland)"],"pubmed_title":["Eosinophils, but Not Type 2 Innate Lymphoid Cells, Are the Predominant Source of Interleukin 4 during the Innate Phase of <i>Leishmania major</i> Infection."],"pmcid":["PMC9331382"],"funding_grant_id":["CRC1181 (project C4); RTG2740 (project A6 and B2); SPP1937 (BO996/5-1 and 5-2;SCHL615/1-1 and 1-2)","Project A87","031L0126"],"pubmed_authors":["Schleicher U","Bogdan C","Debus A","Obermeyer S","Sasse C","Barinberg D"],"additional_accession":[]},"is_claimable":false,"name":"Eosinophils, but Not Type 2 Innate Lymphoid Cells, Are the Predominant Source of Interleukin 4 during the Innate Phase of <i>Leishmania major</i> Infection.","description":"Interleukin (IL)-4 plays a central role in the initiation of a type 2 T helper cell (Th2) response, which leads to non-healing and progressive infections with the protozoan parasite <i>Leishmania</i> (<i>L.</i>) <i>major</i>. Here, we tested the hypothesis that type 2 innate lymphoid cells (ILC2), which promote the development of Th2 cells, form an important source of IL-4 early after intradermal or subcutaneous <i>L. major</i> infection. Lineage-marker negative CD90.2<sup>+</sup>CD127<sup>+</sup>PD1<sup>-</sup> ILC2 were readily detectable in the ear or foot skin, but hardly in the draining lymph nodes of both naïve and <i>L. major</i>-infected self-healing C57BL/6 and non-healing BALB/c mice and made up approximately 20% to 30% of all CD45<sup>+</sup>SiglecF<sup>-</sup> cells. Dermal ILC","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-05-18T13:32:32.153Z","creation":"2025-05-18T13:32:32.153Z"},"accession":"S-EPMC9331382","cross_references":{"pubmed":["35894051"],"doi":["10.3390/pathogens11080828"]}}