{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Shanghai Municipal Science and Technology Major Project","Fudan University-CIOMP Joint Fund","National Key R&D Program of China","Opening Project of Zhejiang Lab","Shanghai Municipal Science and Technology Commission","National Natural Science Foundation of China","Ji Hua Laboratory","Opening Project of Shanghai Robot R&D and Transformation Functional Platform","Shanghai Sailing Program"],"pagination":["3033"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9332801"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(15)"],"pubmed_abstract":["Parylene is used as encapsulating material for medical devices due to its excellent biocompatibility and insulativity. Its performance as the insulating polymer of implantable neural interfaces has been studied in electrolyte solutions and in vivo. Biological tissue in vitro, as a potential environment for characterization and application, is convenient to access in the fabrication lab of polymer and neural electrodes, but there has been little study investigating the behaviors of Parylene in the tissue in vitro. Here, we investigated the electrochemical impedance behaviors of Parylene C polymer coating both in normal saline and in a chilled pig brain in vitro by performing electrochemical impedance spectroscopy (EIS) measurements of platinum (Pt) wire neural electrodes. The electrochemica"],"journal":["Polymers"],"pubmed_title":["Parylene C as an Insulating Polymer for Implantable Neural Interfaces: Acute Electrochemical Impedance Behaviors in Saline and Pig Brain In Vitro."],"pmcid":["PMC9332801"],"funding_grant_id":["2021SHZDZX0103","2021MC0AB01","61904038","19441908200","19441907600","X190021TB190","X190021TB193","FC2019-002","19511132000","2021YFC0122702","KEH2310024","2018SHZDZX01","U1913216","19YF1403600","2018YFC1705800"],"pubmed_authors":["Tao J","Kang X","Zhang J","Zhang Y","Liang J","Le S","Niu L","Zhang L"],"additional_accession":[]},"is_claimable":false,"name":"Parylene C as an Insulating Polymer for Implantable Neural Interfaces: Acute Electrochemical Impedance Behaviors in Saline and Pig Brain In Vitro.","description":"Parylene is used as encapsulating material for medical devices due to its excellent biocompatibility and insulativity. Its performance as the insulating polymer of implantable neural interfaces has been studied in electrolyte solutions and in vivo. Biological tissue in vitro, as a potential environment for characterization and application, is convenient to access in the fabrication lab of polymer and neural electrodes, but there has been little study investigating the behaviors of Parylene in the tissue in vitro. Here, we investigated the electrochemical impedance behaviors of Parylene C polymer coating both in normal saline and in a chilled pig brain in vitro by performing electrochemical impedance spectroscopy (EIS) measurements of platinum (Pt) wire neural electrodes. The electrochemica","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-05-18T13:41:12.587Z","creation":"2025-05-18T13:41:12.587Z"},"accession":"S-EPMC9332801","cross_references":{"pubmed":["35893997"],"doi":["10.3390/polym14153033"]}}