biostudies-literatureMena-Garcia AComunidad of Madrid and European funding from FSE and FEDER programsMINECO/AEI/FEDERMCIN/AEI/10.13039/501100011033Spanish Ministry of Science, Innovation and UniversitiesUniversidad del Cauca3077https://www.ebi.ac.uk/biostudies/studies/S-EPMC9332841biostudies-literatureUnknown14(15)Food supplements of plant origin for weight control are increasingly being demanded by consumers as a way to promote good health. Among them, those based on <i>Garcinia cambogia</i> (GCFS) are widely commercialized considering their bioactive properties, mainly due to (-)-hydroxycitric acid ((-)-HCA). However, recently, controversy has arisen over their safety; thus, further research and continuous monitoring of their composition is required. Hence, in this work, a multi-analytical approach was followed to determine not only (-)-HCA but also other constituents of 18 GCFS, which could be used as quality markers to detect fraudulent practices in these samples. Discrepancies between the declared (-)-HCA content and that experimentally determined were detected by LC-UV in 33% of the samples. MNutrientsQuality Evaluation of Dietary Supplements for Weight Loss Based on <i>Garcinia cambogia</i>.PMC9332841PID2019-106405GB-I00AGL2016-80475-RS2018/BAA-4393, AVANSECAL-II-CM501100005682DIN2019-010849/AEI/10.13039/501100011033Sanz MLBellaizac-Riascos AJRuiz-Matute AIMena-Garcia ARada-Mendoza MChito-Trujillo DMfalseQuality Evaluation of Dietary Supplements for Weight Loss Based on <i>Garcinia cambogia</i>.Food supplements of plant origin for weight control are increasingly being demanded by consumers as a way to promote good health. Among them, those based on <i>Garcinia cambogia</i> (GCFS) are widely commercialized considering their bioactive properties, mainly due to (-)-hydroxycitric acid ((-)-HCA). However, recently, controversy has arisen over their safety; thus, further research and continuous monitoring of their composition is required. Hence, in this work, a multi-analytical approach was followed to determine not only (-)-HCA but also other constituents of 18 GCFS, which could be used as quality markers to detect fraudulent practices in these samples. Discrepancies between the declared (-)-HCA content and that experimentally determined were detected by LC-UV in 33% of the samples. M2022-01-01T00:00:00Z2022 Jul2025-04-19T20:38:46.268Z2025-04-19T20:38:46.268ZS-EPMC93328413589393110.3390/nu14153077