biostudies-literatureUnknown83Streeck H<h4>Background</h4>Immune activation is a significant contributor to HIV pathogenesis and disease progression. In virally-suppressed individuals on ART, low-level immune activation has been linked to several non-infectious comorbid diseases. However, studies have not been systematically performed in sub-Saharan Africa and thus the impact of demographics, ART and regional endemic co-infections on immune activation is not known. We therefore comprehensively evaluated in a large multinational African cohort markers for immune activation and its distribution in various settings.<h4>Methods</h4>2747 specimens from 2240 people living with HIV (PLWH) and 477 without HIV from the observational African Cohort Study (AFRICOS) were analyzed for 13 immune parameters. Samples were collected along with EBioMedicine104182https://www.ebi.ac.uk/biostudies/studies/S-EPMC9334338biostudies-literatureDissecting drivers of immune activation in chronic HIV-1 infection.PMC9334338Ake JAEller LAEller MAKiweewa FMaswai JCrowell TAMaganga LHorn PAHoffmann DHabermann DParikh APPolyak CSEsber ALStreeck HMaestri ARobb MLAFRICOS Study GroupOwuoth JSon GAdamu YMichael NLBahemana EfalseDissecting drivers of immune activation in chronic HIV-1 infection.<h4>Background</h4>Immune activation is a significant contributor to HIV pathogenesis and disease progression. In virally-suppressed individuals on ART, low-level immune activation has been linked to several non-infectious comorbid diseases. However, studies have not been systematically performed in sub-Saharan Africa and thus the impact of demographics, ART and regional endemic co-infections on immune activation is not known. We therefore comprehensively evaluated in a large multinational African cohort markers for immune activation and its distribution in various settings.<h4>Methods</h4>2747 specimens from 2240 people living with HIV (PLWH) and 477 without HIV from the observational African Cohort Study (AFRICOS) were analyzed for 13 immune parameters. Samples were collected along with 2022-01-01T00:00:00Z2022 Sep2025-04-22T03:26:25.95Z2025-04-05T20:44:30.661ZS-EPMC93343383590555910.1016/j.ebiom.2022.104182