biostudies-literatureUnknown11(4)Beraud G<h4>Introduction</h4>We aimed to describe patients with coexisting infective endocarditis (IE) and bacterial meningitis (BM).<h4>Methods</h4>We merged two large prospective cohorts, an IE cohort and a BM cohort, with only cases of definite IE and community-acquired meningitis. We compared patients who had IE and BM concurrently to patients with IE only and BM only.<h4>Results</h4>Among the 1030 included patients, we identified 42 patients with IE-BM (4.1%). Baseline characteristics of patients with IE-BM were mostly similar to those of patients with IE, but meningitis was the predominant presentation at admission (39/42, 92.3%). Causative pathogens were predominantly Streptococcus pneumoniae (18/42, 42.9%) and Staphylococcus aureus (14/42, 33.3%). All pneumococcal IE were associated with BInfectious diseases and therapy1521-1540https://www.ebi.ac.uk/biostudies/studies/S-EPMC9334461biostudies-literatureCombined Bacterial Meningitis and Infective Endocarditis: When Should We Search for the Other When Either One is Diagnosed?PMC9334461Lechiche CVuotto FLemble CToko LSportouch CDao-Dubremetz AGoehringer FAziza FFaucher JFLeport CFrapier JMMagnin-Poull ITande DDaneluzzi VBaraduc RGherissi DVernet Garnier VCordel HAndre PDescotes-Genon VBorlot FLegrix CDekeyser SHenry BLedru SIlles GBoileau JConil JMMrozek NSuy FMarx MGarot DPreau MBattistella PPloy MCBozorg-Grayeli AVittecoq DAlexandra JFHenry PSkalli SHelene JPMeyohas MCBourdon JLPortel LGallien STrouillet JLLafon BWeyne PDoat VObadia JFBouchachi ALafitte AGuimard TLamaury IAtoui AChevalier BSalmon DCabon MVaron EDupont MFillod MMarcon OMartin-Blondel GArmand-Lefevre LMerceron OCazorla CPasquet BRoigt IGarcia MBiron CBaille NMbadi AKaaki MLevy-Bruhl DGandjbakhch IQuaesaet LImbert SEderhy SCanevet CChometon FMerens ABessede EBertei DPiet EChallan-Belval TSelton-Suty CDavid LBruntz JFChabrol ABen Ali APerez PMichon ACaumes EDescamps DChocron SDanchin NPoupard MLaurens EMansouri MKonate ABouche OLhommet CZannad NLacassin FPiroth LCastan BCormier PLaouenan CBalavoine SHoen BPage BGarandeau CRuyer OVerdier FBeraud GZinzius PYFortineau NChristophe CJarrin IPelletier AJaureguiberry SThomas DGaudry STaha MKPhilippart FDelcey VNazerollas PGenoud JLThomas MLorentz CSebire MFauveau ERichemond JCazanave CLe Brun CLepouse CPradier PBarnaud GSoismier NGueit IAEPEI study groupVan Grunderbeeck NJaureguy FGhiglione SDenes EPicot SBrocas ERevest MSegonds CRapp CStrady CCua EAmireche NFonsale NChirouze CChanteperdrix-Marillier VFrappier JMGagneux-Brunon ALecuit MErpelding MLHagege AAppriou MNataf PGachot BBertrand JVernet VRaffi FPorte JMDargere SPlessis PGravet ARaskine LDelahaye FBrasme LPayet BSchmit JLTristan AIung BMakinson ABonacorsi SBousquet APechinot AMonsigny MLefevre Thibaut SAumaitre HFlateau CSon OMicheli SAbouliatim ISchwartz JPoubeau PRomaszko JPGaillot OPoyart CLe Turnier PSunder SDiehl JLColot JDebroucker TBernard LLaurichesse HBoixados MSaroufim CBernard YMourvillier BClair BSimorre BRamanantsoa ALe Moing VCabalion JHenard SLeroy JFreysz LLemee LPrazuck TMetref ZAlla FLanternier FDequin PFSaada MMorquin DKayal SCronier PRamadan RHochart ACSivadon-Tardy VRiche APopovic BTual LBaumard SDesmaretz JLKuhn JMBillard Pomares TArgaud LTubiana SSudrial JRoy CMaurier FMaroni JPDuval XAmrein DNallet OGuinard JHadou TMarcault ELemoine JMales SBuret JBricaire FMan HFraisse TAissa NJaussaud RBourdon SKerneis SChaplain CGrosset MMasse VTartiere LBret LDe Place CGaubert ARousseau FVergnaud MMootien Yoganaden JFloch TWolff MRodermann MBouchemal SDoco-Lecompte TKural Menasche SLoncar GCarteaux JPDelaune DBajolle NDuchene FOziol EWynckel AMouly SBaehrel BLe Chenault VMatray OLevast MBernars GEpaulard OLemaignen AMeyssonnier VBoyer SCambau EChanques GGuelon DRaymond JDeleuze PMezher CGregoire-Faucher VCharlier-Woerther CChaussade HAnguel NPatrat-Delon SLion CHustache-Mathieu LPlainvert CTerrier De La Chaize AVernet-Garnier VAbrial EDimet JBialek SLefort ABland SHuttin OBretonniere CLecuyer HDonnio PYGubavu CNoel VBollaert PEVidal VChidiac CCOMBAT study groupOgielska MEscaut LEvest MChamagne HDeroure BFrachet BVidal MPierrejean DGrentzinger ALesprit PTattevin PBurucoa CArnould MABois Grosse MLetranchant LGroben LBes MCailhol JCelard MRoyer CCamuset GJuvin MEHeliot FDuhoux FForestier EPlassart CRoux ALManchon PDidier Petit KFumery BColin De Verdiere NFerry TPlesiat PMessika-Zeitoun DArista SLesens OMalpote ECaplan MPCarricajo AMellon GLepage LDe Lentdecker PDinh ACarette BSimon MGorenne IMechai FRobin FHouriez PHammoudi NValin NFaibis FRobaday-Voisin SVandenesch FJaffuel SPetit JSPatry IGarcon PTankovic JVerdon RDescloux EThiercelin MCBoubeau PChampagne HCaron FCartry OVitrat VMentre FGodreuil CRoncato MNazeyrollas PCousson JMasson RAcar CSpatz FNguyen YNguyen SBouvet AAbassade PBrun MLanotte PDegand NFabe CJoseph CSotto ATournoux FfalseCombined Bacterial Meningitis and Infective Endocarditis: When Should We Search for the Other When Either One is Diagnosed?<h4>Introduction</h4>We aimed to describe patients with coexisting infective endocarditis (IE) and bacterial meningitis (BM).<h4>Methods</h4>We merged two large prospective cohorts, an IE cohort and a BM cohort, with only cases of definite IE and community-acquired meningitis. We compared patients who had IE and BM concurrently to patients with IE only and BM only.<h4>Results</h4>Among the 1030 included patients, we identified 42 patients with IE-BM (4.1%). Baseline characteristics of patients with IE-BM were mostly similar to those of patients with IE, but meningitis was the predominant presentation at admission (39/42, 92.3%). Causative pathogens were predominantly Streptococcus pneumoniae (18/42, 42.9%) and Staphylococcus aureus (14/42, 33.3%). All pneumococcal IE were associated with B2022-01-01T00:00:00Z2022 Aug2025-04-18T20:20:16.056Z2024-11-20T21:05:55.79ZS-EPMC93344613561895410.1007/s40121-022-00651-7