{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Peng X"],"pubmed_abstract":["Two new patchoulene sesquiterpenoid glycosides (<b>1-2</b>), a natural patchoulane-type sesquiterpenoid (<b>3</b>) and a natural cadinene-type sesquiterpenoid (<b>4</b>), were isolated from the aerial parts of <i>Pogostemon cablin</i> (Blanco) Benth., together with eleven known sesquiterpenoids (<b>5</b>-<b>15</b>) and eleven known flavonoids (<b>16</b>-<b>26</b>). Their chemical structures were elucidated on the basis of spectroscopic methods, including NMR, HRESIMS, IR, and CD spectroscopic data analysis, as well as chemical hydrolysis. The isolated compounds <b>1</b>-<b>13</b> and <b>15</b>-<b>26</b> were tested for inhibitory effects on the proliferation of HepG2 cancer cells. Among them, compounds <b>17</b> and <b>19</b> displayed anti-proliferative effects against HepG2 cells with IC"],"journal":["Frontiers in chemistry"],"pagination":["938851"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9334562"],"repository":["biostudies-literature"],"pubmed_title":["Chemical Constituents With Antiproliferative Activity From <i>Pogostemon cablin</i> (Blanco) Benth."],"pmcid":["PMC9334562"],"pubmed_authors":["Peng X","Wen Y","Fan F","Wu M","Zhang K","Li D","Zhang Y","Gan L","Ang S","Liang P","Yue J"],"additional_accession":[]},"is_claimable":false,"name":"Chemical Constituents With Antiproliferative Activity From <i>Pogostemon cablin</i> (Blanco) Benth.","description":"Two new patchoulene sesquiterpenoid glycosides (<b>1-2</b>), a natural patchoulane-type sesquiterpenoid (<b>3</b>) and a natural cadinene-type sesquiterpenoid (<b>4</b>), were isolated from the aerial parts of <i>Pogostemon cablin</i> (Blanco) Benth., together with eleven known sesquiterpenoids (<b>5</b>-<b>15</b>) and eleven known flavonoids (<b>16</b>-<b>26</b>). Their chemical structures were elucidated on the basis of spectroscopic methods, including NMR, HRESIMS, IR, and CD spectroscopic data analysis, as well as chemical hydrolysis. The isolated compounds <b>1</b>-<b>13</b> and <b>15</b>-<b>26</b> were tested for inhibitory effects on the proliferation of HepG2 cancer cells. Among them, compounds <b>17</b> and <b>19</b> displayed anti-proliferative effects against HepG2 cells with IC","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T03:28:25.047Z","creation":"2025-04-05T20:44:56.277Z"},"accession":"S-EPMC9334562","cross_references":{"pubmed":["35910745"],"doi":["10.3389/fchem.2022.938851"]}}