biostudies-literatureUnknown10Peng XTwo new patchoulene sesquiterpenoid glycosides (1-2), a natural patchoulane-type sesquiterpenoid (3) and a natural cadinene-type sesquiterpenoid (4), were isolated from the aerial parts of Pogostemon cablin (Blanco) Benth., together with eleven known sesquiterpenoids (5-15) and eleven known flavonoids (16-26). Their chemical structures were elucidated on the basis of spectroscopic methods, including NMR, HRESIMS, IR, and CD spectroscopic data analysis, as well as chemical hydrolysis. The isolated compounds 1-13 and 15-26 were tested for inhibitory effects on the proliferation of HepG2 cancer cells. Among them, compounds 17 and 19 displayed anti-proliferative effects against HepG2 cells with ICFrontiers in chemistry938851https://www.ebi.ac.uk/biostudies/studies/S-EPMC9334562biostudies-literatureChemical Constituents With Antiproliferative Activity From Pogostemon cablin (Blanco) Benth.PMC9334562Peng XWen YFan FWu MZhang KLi DZhang YGan LAng SLiang PYue JfalseChemical Constituents With Antiproliferative Activity From Pogostemon cablin (Blanco) Benth.Two new patchoulene sesquiterpenoid glycosides (1-2), a natural patchoulane-type sesquiterpenoid (3) and a natural cadinene-type sesquiterpenoid (4), were isolated from the aerial parts of Pogostemon cablin (Blanco) Benth., together with eleven known sesquiterpenoids (5-15) and eleven known flavonoids (16-26). Their chemical structures were elucidated on the basis of spectroscopic methods, including NMR, HRESIMS, IR, and CD spectroscopic data analysis, as well as chemical hydrolysis. The isolated compounds 1-13 and 15-26 were tested for inhibitory effects on the proliferation of HepG2 cancer cells. Among them, compounds 17 and 19 displayed anti-proliferative effects against HepG2 cells with IC2022-01-01T00:00:00Z20222025-04-22T03:28:25.047Z2025-04-05T20:44:56.277ZS-EPMC93345623591074510.3389/fchem.2022.938851