biostudies-literatureUnknown10Becue C<h4>Background</h4>Involving pediatric nephrological input in the clinical diagnostic work-up of children with short stature, gave rise to the hypothesis that the presence of an underlying renal tubular disorder in children with short stature is possibly underestimated. This study focussed on the added value of calculated urinary fractional excretion (FE) in the early detection of tubular disorders in children with growth failure.<h4>Methods</h4>This trial was designed as an observational study analyzing the medical files of children between 5 and 16 years who had been referred for short stature to the pediatric endocrinology outpatient clinic at the University Hospital Antwerp between 25/01/2015 and 01/03/2019. Based on the laboratory results of the simultaneously taken blood and urine saFrontiers in pediatrics902252https://www.ebi.ac.uk/biostudies/studies/S-EPMC9334702biostudies-literatureScreening for an Underlying Tubulopathy in Children With Growth Failure, Simply Maths?PMC9334702den Brinker MSomers ITrouet DDotremont HLedeganck KJBecue CCeuleers BfalseScreening for an Underlying Tubulopathy in Children With Growth Failure, Simply Maths?<h4>Background</h4>Involving pediatric nephrological input in the clinical diagnostic work-up of children with short stature, gave rise to the hypothesis that the presence of an underlying renal tubular disorder in children with short stature is possibly underestimated. This study focussed on the added value of calculated urinary fractional excretion (FE) in the early detection of tubular disorders in children with growth failure.<h4>Methods</h4>This trial was designed as an observational study analyzing the medical files of children between 5 and 16 years who had been referred for short stature to the pediatric endocrinology outpatient clinic at the University Hospital Antwerp between 25/01/2015 and 01/03/2019. Based on the laboratory results of the simultaneously taken blood and urine sa2022-01-01T00:00:00Z20222025-05-18T13:41:28.088Z2025-05-18T13:41:28.088ZS-EPMC93347023591183010.3389/fped.2022.902252