{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Han Y"],"funding":["Shanghai Municipal Bureau of Economy and Information Technology","Shanghai Science and Technology Fund","National Key Basic Research Program (973 Project)","National Natural Scientific Foundation of China","Special Fund for Science and Technology Innovation of Shanghai Jiao Tong University","863 Project of China"],"pubmed_abstract":["<h4>Objective</h4>Although great progress has been made in the field of siRNA gene therapy, safe, efficient, and targeted delivery of siRNA are still major challenges in siRNA therapeutics.<h4>Methods</h4>We developed an up-conversion nanoparticle-based nanocage system. This system protected the siRNA from being degraded by nucleases in organisms and selectively delivered the siRNAs to the tumor sites, due to modifications of targeted molecules on the surfaces of nanocages and local inhalation.<h4>Results</h4>The siRNAs delivered by the up-conversion nanoparticle nanocages were protected from degradation in transit to the tumor sites, where they accumulated. Compared with the passive target and control groups, the up-conversion nanoparticles based on the nanocage system showed a tumor supp"],"journal":["Cancer biology & medicine"],"pagination":["j.issn.2095-3941.2020.0416"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9334765"],"repository":["biostudies-literature"],"pubmed_title":["Dual-targeted lung cancer therapy <i>via</i> inhalation delivery of UCNP-siRNA-AS1411 nanocages."],"pmcid":["PMC9334765"],"funding_grant_id":["2014AA020700","YG2017MS70","31170961","2015CB931802","YG2015MS62","81028009","81225010","2017FYA0205301","XC-ZXSJ-02-2016-05","13NM1401500","AF0300179","8202010801","81921002"],"pubmed_authors":["Yue C","Liu Y","Yang Y","Sun Q","de la Fuente JM","Han Y","Li B","Cui D"],"additional_accession":[]},"is_claimable":false,"name":"Dual-targeted lung cancer therapy <i>via</i> inhalation delivery of UCNP-siRNA-AS1411 nanocages.","description":"<h4>Objective</h4>Although great progress has been made in the field of siRNA gene therapy, safe, efficient, and targeted delivery of siRNA are still major challenges in siRNA therapeutics.<h4>Methods</h4>We developed an up-conversion nanoparticle-based nanocage system. This system protected the siRNA from being degraded by nucleases in organisms and selectively delivered the siRNAs to the tumor sites, due to modifications of targeted molecules on the surfaces of nanocages and local inhalation.<h4>Results</h4>The siRNAs delivered by the up-conversion nanoparticle nanocages were protected from degradation in transit to the tumor sites, where they accumulated. Compared with the passive target and control groups, the up-conversion nanoparticles based on the nanocage system showed a tumor supp","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-18T15:36:40.105Z","creation":"2025-04-07T02:20:22.098Z"},"accession":"S-EPMC9334765","cross_references":{"pubmed":["34427999"],"doi":["10.20892/j.issn.2095-3941.2020.0416"]}}