biostudies-literatureUnknownLacerda SH2020 Marie Sklodowska-Curie ActionsWellcome TrustPorous materials, such as zeolites, have great potential for biomedical applications, thanks to their ability to accommodate positively charged metal-ions and their facile surface functionalization. Although the latter aspect is important to endow the nanoparticles with chemical/colloidal stability and desired biological properties, the possibility for simple ion-exchange enables easy switching between imaging modalities and/or combination with therapy, depending on the envisioned application. In this study, the nanozeolite Linde type L (LTL) with already confirmed magnetic resonance imaging properties, generated by the paramagnetic gadolinium (Gd^III) in the inner cavities, was successfully radiolabeled with a positron emission tomography (PET)-tracer zirconium-89 (⁸⁹ACS applied materials & interfaceshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9335405biostudies-literatureOn the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study.PMC9335405084052/Z/07/Z088641/Z/09/Z665790Zhang WLacerda ST M de Rosales RDa Silva ISobilo JLerondel SDjanashvili KToth EfalseOn the Versatility of Nanozeolite Linde Type L for Biomedical Applications: Zirconium-89 Radiolabeling and In Vivo Positron Emission Tomography Study.Porous materials, such as zeolites, have great potential for biomedical applications, thanks to their ability to accommodate positively charged metal-ions and their facile surface functionalization. Although the latter aspect is important to endow the nanoparticles with chemical/colloidal stability and desired biological properties, the possibility for simple ion-exchange enables easy switching between imaging modalities and/or combination with therapy, depending on the envisioned application. In this study, the nanozeolite Linde type L (LTL) with already confirmed magnetic resonance imaging properties, generated by the paramagnetic gadolinium (Gd^III) in the inner cavities, was successfully radiolabeled with a positron emission tomography (PET)-tracer zirconium-89 (⁸⁹2022-01-01T00:00:00Z2022 Jul2025-04-27T01:11:34.694Z2025-04-06T18:07:39.123ZS-EPMC93354053583028510.1021/acsami.2c03841