{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fromm K"],"funding":["Swiss National Science Foundation"],"pagination":["913434"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9336547"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["<i>Bartonella</i> spp. are Gram-negative facultative intracellular pathogens that infect diverse mammals and cause a long-lasting intra-erythrocytic bacteremia in their natural host. These bacteria translocate <i>Bartonella</i> effector proteins (Beps) into host cells <i>via</i> their VirB/VirD4 type 4 secretion system (T4SS) in order to subvert host cellular functions, thereby leading to the downregulation of innate immune responses. Most studies on the functional analysis of the VirB/VirD4 T4SS and the Beps were performed with the major zoonotic pathogen <i>Bartonella henselae</i> for which efficient <i>in vitro</i> infection protocols have been established. However, its natural host, the cat, is unsuitable as an experimental infection model. <i>In vivo</i> studies were mostly confined t"],"journal":["Frontiers in microbiology"],"pubmed_title":["<i>Bartonella taylorii</i>: A Model Organism for Studying <i>Bartonella</i> Infection <i>in vitro</i> and <i>in vivo</i>."],"pmcid":["PMC9336547"],"funding_grant_id":["201273"],"pubmed_authors":["Fromm K","Wagner S","Bohn E","Boegli A","Ortelli M","Wagner A","Malmsheimer S","Dehio C"],"additional_accession":[]},"is_claimable":false,"name":"<i>Bartonella taylorii</i>: A Model Organism for Studying <i>Bartonella</i> Infection <i>in vitro</i> and <i>in vivo</i>.","description":"<i>Bartonella</i> spp. are Gram-negative facultative intracellular pathogens that infect diverse mammals and cause a long-lasting intra-erythrocytic bacteremia in their natural host. These bacteria translocate <i>Bartonella</i> effector proteins (Beps) into host cells <i>via</i> their VirB/VirD4 type 4 secretion system (T4SS) in order to subvert host cellular functions, thereby leading to the downregulation of innate immune responses. Most studies on the functional analysis of the VirB/VirD4 T4SS and the Beps were performed with the major zoonotic pathogen <i>Bartonella henselae</i> for which efficient <i>in vitro</i> infection protocols have been established. However, its natural host, the cat, is unsuitable as an experimental infection model. <i>In vivo</i> studies were mostly confined t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-20T03:36:27.071Z","creation":"2024-11-21T09:50:13.488Z"},"accession":"S-EPMC9336547","cross_references":{"pubmed":["35910598"],"doi":["10.3389/fmicb.2022.913434"]}}