{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shetty SP"],"funding":["National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["e0271453"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9337670"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(7)"],"pubmed_abstract":["Selenoproteins contain the 21st amino acid, selenocysteine (Sec), which is incorporated at select UGA codons when a specialized hairpin sequence, the Sec insertion sequence (SECIS) element, is present in the 3' UTR. Aside from the SECIS, selenoprotein mRNA 3' UTRs are not conserved between different selenoproteins within a species. In contrast, the 3'-UTR of a given selenoprotein is often conserved across species, which supports the hypothesis that cis-acting elements in the 3'-UTR other than the SECIS exert post-transcriptional control on selenoprotein expression. In order to determine the function of one such SECIS context, we chose to focus on the plasma selenoprotein, SELENOP, which is required to maintain selenium homeostasis as a selenium transport protein that contains 10 Sec residu"],"journal":["PloS one"],"pubmed_title":["The selenoprotein P 3' untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation."],"pmcid":["PMC9337670"],"funding_grant_id":["R01GM077073","R01 GM077073"],"pubmed_authors":["Kiledjian NT","Copeland PR","Shetty SP"],"additional_accession":[]},"is_claimable":false,"name":"The selenoprotein P 3' untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation.","description":"Selenoproteins contain the 21st amino acid, selenocysteine (Sec), which is incorporated at select UGA codons when a specialized hairpin sequence, the Sec insertion sequence (SECIS) element, is present in the 3' UTR. Aside from the SECIS, selenoprotein mRNA 3' UTRs are not conserved between different selenoproteins within a species. In contrast, the 3'-UTR of a given selenoprotein is often conserved across species, which supports the hypothesis that cis-acting elements in the 3'-UTR other than the SECIS exert post-transcriptional control on selenoprotein expression. In order to determine the function of one such SECIS context, we chose to focus on the plasma selenoprotein, SELENOP, which is required to maintain selenium homeostasis as a selenium transport protein that contains 10 Sec residu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T11:16:58.257Z","creation":"2025-04-19T11:16:58.257Z"},"accession":"S-EPMC9337670","cross_references":{"pubmed":["35905095"],"doi":["10.1371/journal.pone.0271453"]}}