{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(29)"],"submitter":["Ahmed N"],"pubmed_abstract":["With an ever-growing emphasis on sustainable synthesis, aerobic C-H activation (the use of oxygen in air to activate C-H bonds) represents a highly attractive conduit for the development of novel synthetic methodologies. Herein, we report the air mediated functionalisation of various saturated heterocycles and ethers <i>via</i> aerobically generated radical intermediates to form new C-C bonds using acetylenic and vinyl triflones as radical acceptors. This enables access to a variety of acetylenic and vinyl substituted saturated heterocycles that are rich in synthetic value. Mechanistic studies and control reactions support an aerobic radical-based C-H activation mechanism."],"journal":["Chemical science"],"pagination":["8626-8633"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9337743"],"repository":["biostudies-literature"],"pubmed_title":["Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C-H activation and C-C bond formation."],"pmcid":["PMC9337743"],"pubmed_authors":["Spears RJ","Chudasama V","Sheppard TD","Ahmed N"],"additional_accession":[]},"is_claimable":false,"name":"Functionalisation of ethereal-based saturated heterocycles with concomitant aerobic C-H activation and C-C bond formation.","description":"With an ever-growing emphasis on sustainable synthesis, aerobic C-H activation (the use of oxygen in air to activate C-H bonds) represents a highly attractive conduit for the development of novel synthetic methodologies. Herein, we report the air mediated functionalisation of various saturated heterocycles and ethers <i>via</i> aerobically generated radical intermediates to form new C-C bonds using acetylenic and vinyl triflones as radical acceptors. This enables access to a variety of acetylenic and vinyl substituted saturated heterocycles that are rich in synthetic value. Mechanistic studies and control reactions support an aerobic radical-based C-H activation mechanism.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-05-29T20:04:00.147Z","creation":"2024-11-06T15:59:40.299Z"},"accession":"S-EPMC9337743","cross_references":{"pubmed":["35974756"],"doi":["10.1039/d2sc01626e"]}}