biostudies-literatureUnknown13(29)Ahmed NWith an ever-growing emphasis on sustainable synthesis, aerobic C-H activation (the use of oxygen in air to activate C-H bonds) represents a highly attractive conduit for the development of novel synthetic methodologies. Herein, we report the air mediated functionalisation of various saturated heterocycles and ethers <i>via</i> aerobically generated radical intermediates to form new C-C bonds using acetylenic and vinyl triflones as radical acceptors. This enables access to a variety of acetylenic and vinyl substituted saturated heterocycles that are rich in synthetic value. Mechanistic studies and control reactions support an aerobic radical-based C-H activation mechanism.Chemical science8626-8633https://www.ebi.ac.uk/biostudies/studies/S-EPMC9337743biostudies-literatureFunctionalisation of ethereal-based saturated heterocycles with concomitant aerobic C-H activation and C-C bond formation.PMC9337743Spears RJChudasama VSheppard TDAhmed NfalseFunctionalisation of ethereal-based saturated heterocycles with concomitant aerobic C-H activation and C-C bond formation.With an ever-growing emphasis on sustainable synthesis, aerobic C-H activation (the use of oxygen in air to activate C-H bonds) represents a highly attractive conduit for the development of novel synthetic methodologies. Herein, we report the air mediated functionalisation of various saturated heterocycles and ethers <i>via</i> aerobically generated radical intermediates to form new C-C bonds using acetylenic and vinyl triflones as radical acceptors. This enables access to a variety of acetylenic and vinyl substituted saturated heterocycles that are rich in synthetic value. Mechanistic studies and control reactions support an aerobic radical-based C-H activation mechanism.2022-01-01T00:00:00Z2022 Jul2025-05-29T20:04:00.147Z2024-11-06T15:59:40.299ZS-EPMC93377433597475610.1039/d2sc01626e