{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peris L"],"funding":["France Alzheimer","Henry and Marilyn Taub Foundation","Ramón Areces Foundation","NIA NIH HHS","ANR","NIA","NIH","Thompson Foundation","NINDS","University Grenoble Alpes","INSERM","Columbia University","CNRS","NINDS NIH HHS","CEA"],"pagination":["2486-2506"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9337816"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["145(7)"],"pubmed_abstract":["Microtubules play fundamental roles in the maintenance of neuronal processes and in synaptic function and plasticity. While dynamic microtubules are mainly composed of tyrosinated tubulin, long-lived microtubules contain detyrosinated tubulin, suggesting that the tubulin tyrosination/detyrosination cycle is a key player in the maintenance of microtubule dynamics and neuronal homeostasis, conditions that go awry in neurodegenerative diseases. In the tyrosination/detyrosination cycle, the C-terminal tyrosine of α-tubulin is removed by tubulin carboxypeptidases and re-added by tubulin tyrosine ligase (TTL). Here we show that TTL heterozygous mice exhibit decreased tyrosinated microtubules, reduced dendritic spine density and both synaptic plasticity and memory deficits. We further report decr"],"journal":["Brain : a journal of neurology"],"pubmed_title":["Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease."],"pmcid":["PMC9337816"],"funding_grant_id":["CAPAlz-AAP SM 2018","RO3 AG060025","R21 NS120076-01","R01 AG050658","AARF-20-685875","RO1 AG050658","R21 NS120076","ANR-20-CE16-0021","R03 AG060025","R56 AG050658"],"pubmed_authors":["Corrao C","Pero ME","Brocard J","Sproul A","Delagrange P","Soleilhac JM","Andrieux A","Goldberg Y","Bartolini F","Moutin MJ","Payet F","Blanca Ramirez M","Peris L","Bosc C","Gory-Faure S","Lante F","Buisson A","Parato J","Qu X","Di Cara B","Martinez-Hernandez J","Kumar A","Falivelli G"],"additional_accession":[]},"is_claimable":false,"name":"Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer's disease.","description":"Microtubules play fundamental roles in the maintenance of neuronal processes and in synaptic function and plasticity. While dynamic microtubules are mainly composed of tyrosinated tubulin, long-lived microtubules contain detyrosinated tubulin, suggesting that the tubulin tyrosination/detyrosination cycle is a key player in the maintenance of microtubule dynamics and neuronal homeostasis, conditions that go awry in neurodegenerative diseases. In the tyrosination/detyrosination cycle, the C-terminal tyrosine of α-tubulin is removed by tubulin carboxypeptidases and re-added by tubulin tyrosine ligase (TTL). Here we show that TTL heterozygous mice exhibit decreased tyrosinated microtubules, reduced dendritic spine density and both synaptic plasticity and memory deficits. We further report decr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-06-22T03:16:11.334Z","creation":"2025-04-19T11:15:12.299Z"},"accession":"S-EPMC9337816","cross_references":{"pubmed":["35148384"],"doi":["10.1093/brain/awab436"]}}