biostudies-literatureWang JNational Natural Science Foundation of China4411https://www.ebi.ac.uk/biostudies/studies/S-EPMC9338060biostudies-literatureUnknown13(1)Robust ionic sensing materials that are both fatigue-resistant and self-healable like human skin are essential for soft electronics and robotics with extended service life. However, most existing self-healable artificial ionic skins produced on the basis of network reconfiguration suffer from a low fatigue threshold due to the easy fracture of low-energy amorphous polymer chains with susceptible crack propagation. Here we engineer a fatigue-free yet fully healable hybrid ionic skin toughened by a high-energy, self-healable elastic nanomesh, resembling the repairable nanofibrous interwoven structure of human skin. Such a design affords a superhigh fatigue threshold of 2950 J m^-2 while maintaining skin-like compliance, stretchability, and strain-adaptive stiffening response. MoreoNature communicationsFatigue-free artificial ionic skin toughened by self-healable elastic nanomesh.PMC933806021991123, 51873035, and 51733003Wei PSun SWu PWu BWang JfalseFatigue-free artificial ionic skin toughened by self-healable elastic nanomesh.Robust ionic sensing materials that are both fatigue-resistant and self-healable like human skin are essential for soft electronics and robotics with extended service life. However, most existing self-healable artificial ionic skins produced on the basis of network reconfiguration suffer from a low fatigue threshold due to the easy fracture of low-energy amorphous polymer chains with susceptible crack propagation. Here we engineer a fatigue-free yet fully healable hybrid ionic skin toughened by a high-energy, self-healable elastic nanomesh, resembling the repairable nanofibrous interwoven structure of human skin. Such a design affords a superhigh fatigue threshold of 2950 J m^-2 while maintaining skin-like compliance, stretchability, and strain-adaptive stiffening response. Moreo2022-01-01T00:00:00Z2022 Jul2025-04-04T03:40:58.622Z2025-04-04T03:40:58.622ZS-EPMC93380603590623810.1038/s41467-022-32140-3