{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(1)"],"submitter":["Mita Y"],"funding":["Sumitomo Pharma Co., Ltd. for Partnership to Realize Innovative Seeds and Medicines"],"pubmed_abstract":["Muscle fibres are broadly categorised into types I and II; the fibre-type ratio determines the contractile and metabolic properties of skeletal muscle tissue. The maintenance of type I fibres is essential for the prevention of obesity and the treatment of muscle atrophy caused by type 2 diabetes or unloading. Some reports suggest that myokines are related to muscle fibre type determination. We thus explored whether a myokine determines whether satellite cells differentiate to type I fibres. By examining the fibre types separately, we identified R-spondin 3 (Rspo3) as a myokine of interest, a secreted protein known as an activator of Wnt signalling pathways. To examine whether Rspo3 induces type I fibres, primary myoblasts prepared from mouse soleus muscles were exposed to a differentiation"],"journal":["Scientific reports"],"pagination":["13020"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9338073"],"repository":["biostudies-literature"],"pubmed_title":["R-spondin3 is a myokine that differentiates myoblasts to type I fibres."],"pmcid":["PMC9338073"],"pubmed_authors":["Mita Y","Manabe Y","Fujii NL","Hamaguchi H","Zhu H","Furuichi Y"],"additional_accession":[]},"is_claimable":false,"name":"R-spondin3 is a myokine that differentiates myoblasts to type I fibres.","description":"Muscle fibres are broadly categorised into types I and II; the fibre-type ratio determines the contractile and metabolic properties of skeletal muscle tissue. The maintenance of type I fibres is essential for the prevention of obesity and the treatment of muscle atrophy caused by type 2 diabetes or unloading. Some reports suggest that myokines are related to muscle fibre type determination. We thus explored whether a myokine determines whether satellite cells differentiate to type I fibres. By examining the fibre types separately, we identified R-spondin 3 (Rspo3) as a myokine of interest, a secreted protein known as an activator of Wnt signalling pathways. To examine whether Rspo3 induces type I fibres, primary myoblasts prepared from mouse soleus muscles were exposed to a differentiation","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-27T01:16:14.381Z","creation":"2025-04-06T18:08:52.841Z"},"accession":"S-EPMC9338073","cross_references":{"pubmed":["35906363"],"doi":["10.1038/s41598-022-16640-2"]}}