biostudies-literatureUnknown12(1)Jang YCHormone replacement therapy (HRT) is widely used to relieve menopausal symptoms; however, it remains unclear whether the use of HRT was associated with gastric cancer. We conducted a systematic review and meta-analysis to synthesize available evidence. This study followed the PRISMA guideline to report meta-analysis. PubMed, Embase, and Cochrane library were searched from conception through 23 February 2022. Eligible studies reporting risk of gastric cancer after HRT were screened and accessed by two independent reviewers. Random-effects meta-analysis was used to calculate pooled risk estimate as relative risk (RR, 95% CI). Pre-established review protocol was registered in PROSPERO (CRD42021281260). Among the 1095 articles identified, we included 11 studies with 1,919,089 women in this metScientific reports12997https://www.ebi.ac.uk/biostudies/studies/S-EPMC9338312biostudies-literatureAssociation of hormone replacement therapy with risk of gastric cancer: a systematic review and meta-analysis.PMC9338312Leung CYHuang HLJang YCfalseAssociation of hormone replacement therapy with risk of gastric cancer: a systematic review and meta-analysis.Hormone replacement therapy (HRT) is widely used to relieve menopausal symptoms; however, it remains unclear whether the use of HRT was associated with gastric cancer. We conducted a systematic review and meta-analysis to synthesize available evidence. This study followed the PRISMA guideline to report meta-analysis. PubMed, Embase, and Cochrane library were searched from conception through 23 February 2022. Eligible studies reporting risk of gastric cancer after HRT were screened and accessed by two independent reviewers. Random-effects meta-analysis was used to calculate pooled risk estimate as relative risk (RR, 95% CI). Pre-established review protocol was registered in PROSPERO (CRD42021281260). Among the 1095 articles identified, we included 11 studies with 1,919,089 women in this met2022-01-01T00:00:00Z2022 Jul2025-04-22T03:29:15.141Z2025-04-05T20:42:14.147ZS-EPMC93383123590638110.1038/s41598-022-17345-2