{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fulghum K"],"funding":["NIEHS NIH HHS","NHLBI NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["479-494"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9338340"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(4)"],"pubmed_abstract":["Although the structural and functional effects of exercise on the heart are well established, the metabolic changes that occur in the heart during and after exercise remain unclear. In this study, we used metabolomics to assess time-dependent changes in the murine cardiac metabolome following 1 session of treadmill exercise. After the exercise bout, we also recorded blood lactate, glucose, and ketone body levels and measured cardiac mitochondrial respiration. In both male and female mice, moderate- and high-intensity exercise acutely increased blood lactate levels. In both sexes, low- and moderate-intensity exercise augmented circulating 3-hydroxybutryrate levels immediately after the exercise bout; however, only in female mice did high-intensity exercise increase 3-hydroxybutyrate levels,"],"journal":["Journal of sport and health science"],"pubmed_title":["Influence of biological sex and exercise on murine cardiac metabolism."],"pmcid":["PMC9338340"],"funding_grant_id":["P30 GM127607","R01 HL147844","R01 HL130174","P01 HL078825","HL130174","HL078825","GM127607","R01 ES028268","HL154663","HL147844","F31 HL154663"],"pubmed_authors":["Fulghum K","Jones SP","Hill BG","Collins HE"],"additional_accession":[]},"is_claimable":false,"name":"Influence of biological sex and exercise on murine cardiac metabolism.","description":"Although the structural and functional effects of exercise on the heart are well established, the metabolic changes that occur in the heart during and after exercise remain unclear. In this study, we used metabolomics to assess time-dependent changes in the murine cardiac metabolome following 1 session of treadmill exercise. After the exercise bout, we also recorded blood lactate, glucose, and ketone body levels and measured cardiac mitochondrial respiration. In both male and female mice, moderate- and high-intensity exercise acutely increased blood lactate levels. In both sexes, low- and moderate-intensity exercise augmented circulating 3-hydroxybutryrate levels immediately after the exercise bout; however, only in female mice did high-intensity exercise increase 3-hydroxybutyrate levels,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-18T22:23:27.327Z","creation":"2025-04-07T10:06:35.685Z"},"accession":"S-EPMC9338340","cross_references":{"pubmed":["35688382"],"doi":["10.1016/j.jshs.2022.06.001"]}}