{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Adderley J"],"funding":["Yourgene Health Singapore","the Australian Research Council","the Australian National Health and Medical Research Council (NHMRC)","the Australian National Health and Medical Research Council"],"pagination":["273"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9338626"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Gaining insight into molecular signalling pathways of socioeconomically important parasitic nematodes has implications for understanding their molecular biology and for developing novel anthelmintic interventions.<h4>Methods</h4>Here, we evaluated the use of a human antibody-based microarray to explore conserved elements of the signalome in the barber's pole worm Haemonchus contortus. To do this, we prepared extracts from mixed-sex (female and male) adult worms and third-stage larvae (L3s), incubated these extracts on the antibody microarray and then measured the amounts of antibody-bound proteins ('signal intensity').<h4>Results</h4>In total, 878 signals were classified into two distinct categories: signals that were higher for adults than for larvae of H. contortus (n "],"journal":["Parasites & vectors"],"pubmed_title":["Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus."],"pmcid":["PMC9338626"],"funding_grant_id":["APP2003712"],"pubmed_authors":["Zheng Y","Gasser RB","Wang T","Adderley J","Doerig C","Young ND","Ma G"],"additional_accession":[]},"is_claimable":false,"name":"Repurposing of a human antibody-based microarray to explore conserved components of the signalome of the parasitic nematode Haemonchus contortus.","description":"<h4>Background</h4>Gaining insight into molecular signalling pathways of socioeconomically important parasitic nematodes has implications for understanding their molecular biology and for developing novel anthelmintic interventions.<h4>Methods</h4>Here, we evaluated the use of a human antibody-based microarray to explore conserved elements of the signalome in the barber's pole worm Haemonchus contortus. To do this, we prepared extracts from mixed-sex (female and male) adult worms and third-stage larvae (L3s), incubated these extracts on the antibody microarray and then measured the amounts of antibody-bound proteins ('signal intensity').<h4>Results</h4>In total, 878 signals were classified into two distinct categories: signals that were higher for adults than for larvae of H. contortus (n ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-05-28T04:04:47.728Z","creation":"2025-02-19T03:29:33.314Z"},"accession":"S-EPMC9338626","cross_references":{"pubmed":["35907892"],"doi":["10.1186/s13071-022-05400-w"]}}