{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Liu S"],"pubmed_abstract":["1,2-Amino oxygenation of alkenes has emerged as one of the most straightforward synthetic methods to produce β-amino alcohols, which are important organic building blocks. Thus, a practical synthetic strategy for 1,2-amino oxygenation is highly desirable. Here, we reported an electro-oxidative intermolecular 1,2-amino oxygenation of alkenes with hydrogen evolution, removing the requirement of extra-oxidant. Using commercial oxygen and nitrogen sources as starting materials, this method provides a cheap, scalable, and efficient route to a set of valuable β-amino alcohol derivatives. Moreover, the merit of this protocol has been exhibited by its broad substrate scope and good application in continuous-flow reactors. Furthermore, this method can be extended to other amino-functionalization of"],"journal":["Nature communications"],"pagination":["4430"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9338937"],"repository":["biostudies-literature"],"pubmed_title":["1,2-Amino oxygenation of alkenes with hydrogen evolution reaction."],"pmcid":["PMC9338937"],"pubmed_authors":["Wang P","Huang Z","Wang S","Wang T","Liu S","Lei A"],"additional_accession":[]},"is_claimable":false,"name":"1,2-Amino oxygenation of alkenes with hydrogen evolution reaction.","description":"1,2-Amino oxygenation of alkenes has emerged as one of the most straightforward synthetic methods to produce β-amino alcohols, which are important organic building blocks. Thus, a practical synthetic strategy for 1,2-amino oxygenation is highly desirable. Here, we reported an electro-oxidative intermolecular 1,2-amino oxygenation of alkenes with hydrogen evolution, removing the requirement of extra-oxidant. Using commercial oxygen and nitrogen sources as starting materials, this method provides a cheap, scalable, and efficient route to a set of valuable β-amino alcohol derivatives. Moreover, the merit of this protocol has been exhibited by its broad substrate scope and good application in continuous-flow reactors. Furthermore, this method can be extended to other amino-functionalization of","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-22T03:35:01.122Z","creation":"2025-04-05T20:43:24.815Z"},"accession":"S-EPMC9338937","cross_references":{"pubmed":["35908027"],"doi":["10.1038/s41467-022-32084-8"]}}