{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(7)"],"submitter":["Bai FR"],"pubmed_abstract":["Spermatogenesis is a complex biological process that produces haploid spermatozoa and requires precise regulation by many tissue-specific factors. In this study, we explored the role and mechanism of Fork head box J2 (FOXJ2, which is highly expressed in spermatocytes) in the regulation of spermatogenesis using a germline-specific conditional Foxj2 knock-in mouse model (Stra8-Cre; Foxj2 <sup>tg/tg</sup> mouse). Foxj2 overexpression in mouse testes led to spermatogenesis failure, which started at the initiation of meiosis, and resulted in male infertility. Lysosomes and autophagy-related genes were upregulated in Stra8-cre; Foxj2 <sup>tg/tg</sup> mouse testes and the number of autolysosomes in the spermatocytes in Stra8-cre; Foxj2 <sup>tg/tg</sup> mice was increased. Chromatin immunoprecipit"],"journal":["Cell death & disease"],"pagination":["665"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9338950"],"repository":["biostudies-literature"],"pubmed_title":["Germline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulation."],"pmcid":["PMC9338950"],"pubmed_authors":["Wu JW","Qian WZ","Cai C","Bai FR","Lv H","Hu YQ","Jiang ZX","Wu YJ","Wu QQ"],"additional_accession":[]},"is_claimable":false,"name":"Germline FOXJ2 overexpression causes male infertility via aberrant autophagy activation by LAMP2A upregulation.","description":"Spermatogenesis is a complex biological process that produces haploid spermatozoa and requires precise regulation by many tissue-specific factors. In this study, we explored the role and mechanism of Fork head box J2 (FOXJ2, which is highly expressed in spermatocytes) in the regulation of spermatogenesis using a germline-specific conditional Foxj2 knock-in mouse model (Stra8-Cre; Foxj2 <sup>tg/tg</sup> mouse). Foxj2 overexpression in mouse testes led to spermatogenesis failure, which started at the initiation of meiosis, and resulted in male infertility. Lysosomes and autophagy-related genes were upregulated in Stra8-cre; Foxj2 <sup>tg/tg</sup> mouse testes and the number of autolysosomes in the spermatocytes in Stra8-cre; Foxj2 <sup>tg/tg</sup> mice was increased. Chromatin immunoprecipit","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-19T20:34:57.17Z","creation":"2025-04-19T20:34:57.17Z"},"accession":"S-EPMC9338950","cross_references":{"pubmed":["35908066"],"doi":["10.1038/s41419-022-05116-w"]}}