{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xie M"],"funding":["Natural Science Foundation of Hunan Province in China","Hunan Provincial Key R&D Program Project","the National Natural Science Foundation of China"],"pagination":["13101"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9338971"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systems. Immunopathology believes that abnormal T cell function and excessive production of autoantibodies by B cells are involved in multi-organ damage. Human umbilical cord mesenchymal stem cells (hUCMSCs) therapies have endowed with promise in SLE, while the function of MSC-derived extracellular vesicles (MSC-EVs) was still unclear. Extracellular vesicles (EVs) are subcellular components secreted by a paracellular mechanism and are essentially a group of nanoparticles. EVs play a vital role in cell-to-cell communication by acting as biological transporters. New evidence has shown beneficial effects of MSC-EVs on autoimmune diseases, such as their immunomodulatory properties. In this study, we investigated whe"],"journal":["Scientific reports"],"pubmed_title":["Human umbilical cord mesenchymal stem cells derived extracellular vesicles regulate acquired immune response of lupus mouse in vitro."],"pmcid":["PMC9338971"],"funding_grant_id":["No. 2020SK2084","No. 82070758","No. 2019JJ40413"],"pubmed_authors":["Tian J","Hun M","Li C","Xie M","She Z","Wen C","Luo S","Wan W","Wu F","Mao J"],"additional_accession":[]},"is_claimable":false,"name":"Human umbilical cord mesenchymal stem cells derived extracellular vesicles regulate acquired immune response of lupus mouse in vitro.","description":"Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systems. Immunopathology believes that abnormal T cell function and excessive production of autoantibodies by B cells are involved in multi-organ damage. Human umbilical cord mesenchymal stem cells (hUCMSCs) therapies have endowed with promise in SLE, while the function of MSC-derived extracellular vesicles (MSC-EVs) was still unclear. Extracellular vesicles (EVs) are subcellular components secreted by a paracellular mechanism and are essentially a group of nanoparticles. EVs play a vital role in cell-to-cell communication by acting as biological transporters. New evidence has shown beneficial effects of MSC-EVs on autoimmune diseases, such as their immunomodulatory properties. In this study, we investigated whe","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-04T08:44:58.24Z","creation":"2025-04-04T08:44:58.24Z"},"accession":"S-EPMC9338971","cross_references":{"pubmed":["35908050"],"doi":["10.1038/s41598-022-17331-8"]}}