{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mohamed H"],"funding":["TaiShan Industrial Experts Programme","National Natural Science Foundation of China"],"pagination":["13111"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9338991"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["This study aimed to improve lipid and gamma-linolenic acid (GLA) production of an oleaginous fungus, Mucor plumbeus, through coculturing with Bacillus subtilis bacteria, optimising the environmental and nutritional culture conditions, and scaling them for batch fermentation. The maximum levels of biomass, lipid, fatty acid, and GLA in a 5 L bioreactor containing cellobiose and ammonium sulfate as the optimal carbon and nitrogen sources, respectively, achieved during the coculturing processes were 14.5 ± 0.4 g/L, 41.5 ± 1.3, 24 ± 0.8, and 20 ± 0.5%, respectively. This strategy uses cellobiose in place of glucose, decreasing production costs. The nutritional and abiotic factor results suggest that the highest production efficiency is achieved at 6.5 pH, 30 °C temperature, 10% (v/v) inoculum "],"journal":["Scientific reports"],"pubmed_title":["Coculturing of Mucor plumbeus and Bacillus subtilis bacterium as an efficient fermentation strategy to enhance fungal lipid and gamma-linolenic acid (GLA) production."],"pmcid":["PMC9338991"],"funding_grant_id":["20160101","31670064","31972851"],"pubmed_authors":["Yang W","Naz T","Shah AM","Sadaqat B","Awad MF","Mohamed H","Nazir Y","Song Y"],"additional_accession":[]},"is_claimable":false,"name":"Coculturing of Mucor plumbeus and Bacillus subtilis bacterium as an efficient fermentation strategy to enhance fungal lipid and gamma-linolenic acid (GLA) production.","description":"This study aimed to improve lipid and gamma-linolenic acid (GLA) production of an oleaginous fungus, Mucor plumbeus, through coculturing with Bacillus subtilis bacteria, optimising the environmental and nutritional culture conditions, and scaling them for batch fermentation. The maximum levels of biomass, lipid, fatty acid, and GLA in a 5 L bioreactor containing cellobiose and ammonium sulfate as the optimal carbon and nitrogen sources, respectively, achieved during the coculturing processes were 14.5 ± 0.4 g/L, 41.5 ± 1.3, 24 ± 0.8, and 20 ± 0.5%, respectively. This strategy uses cellobiose in place of glucose, decreasing production costs. The nutritional and abiotic factor results suggest that the highest production efficiency is achieved at 6.5 pH, 30 °C temperature, 10% (v/v) inoculum ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-07-14T16:02:24.327Z","creation":"2024-11-15T06:46:19.39Z"},"accession":"S-EPMC9338991","cross_references":{"pubmed":["35908106"],"doi":["10.1038/s41598-022-17442-2"]}}