{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31(9)"],"submitter":["Liu K"],"pubmed_abstract":["The study aimed to characterize phenolic compounds of the <i>Inonotus sanghuang</i>'s ethyl-acetate fraction (EAF) and assess the neuroprotective effect of EAF using the H<sub>2</sub>O<sub>2</sub>-treated primary cortical neuronal cells (PCNC) model. Using HPLC-ECD, 5 phenolics were identified and quantified from EAF. H<sub>2</sub>O<sub>2</sub>-treated PCNC experiments in vitro showed that pretreatment with EAF increased the GSH-PX and SOD activities and reduced the NO, MDA, and Aβ contents. Furthermore, EAF suppressed the production of IL-1β, IFN-γ, IL-6, and TNF-α in H<sub>2</sub>O<sub>2</sub>-treated PCNC. Other mechanisms found that EAF reduced Bax, caspase 9, and caspase 3 expressions at the mRNA and protein levels while increasing Bcl-2 expression at the mRNA and protein levels. Thes"],"journal":["Food science and biotechnology"],"pagination":["1213-1223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9339070"],"repository":["biostudies-literature"],"pubmed_title":["Phenolic composition and neuroprotective effects of the ethyl-acetate fraction from <i>Inonotus sanghuang</i> against H<sub>2</sub>O<sub>2</sub>-induced apoptotic cell death of primary cortical neuronal cells."],"pmcid":["PMC9339070"],"pubmed_authors":["Liu Y","Liu K","Huai Y","Hu H","Xiao X","Qi C","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Phenolic composition and neuroprotective effects of the ethyl-acetate fraction from <i>Inonotus sanghuang</i> against H<sub>2</sub>O<sub>2</sub>-induced apoptotic cell death of primary cortical neuronal cells.","description":"The study aimed to characterize phenolic compounds of the <i>Inonotus sanghuang</i>'s ethyl-acetate fraction (EAF) and assess the neuroprotective effect of EAF using the H<sub>2</sub>O<sub>2</sub>-treated primary cortical neuronal cells (PCNC) model. Using HPLC-ECD, 5 phenolics were identified and quantified from EAF. H<sub>2</sub>O<sub>2</sub>-treated PCNC experiments in vitro showed that pretreatment with EAF increased the GSH-PX and SOD activities and reduced the NO, MDA, and Aβ contents. Furthermore, EAF suppressed the production of IL-1β, IFN-γ, IL-6, and TNF-α in H<sub>2</sub>O<sub>2</sub>-treated PCNC. Other mechanisms found that EAF reduced Bax, caspase 9, and caspase 3 expressions at the mRNA and protein levels while increasing Bcl-2 expression at the mRNA and protein levels. Thes","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T18:42:03.596Z","creation":"2025-04-04T18:42:03.596Z"},"accession":"S-EPMC9339070","cross_references":{"pubmed":["35919355"],"doi":["10.1007/s10068-022-01107-x"]}}