{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Strikwerda-Brown C"],"funding":["NIA NIH HHS"],"pagination":["975-985"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9339146"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(10)"],"pubmed_abstract":["<h4>Importance</h4>National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD).<h4>Objective</h4>To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at near-term risk of developing symptomatic AD.<h4>Design, setting, and participants</h4>This longitudinal cohort study used data from 4 independent population-based cohorts (PREVENT-AD, HABS, AIBL, and Knight ADRC) collected between 2003 and 2021. Participants were older adults without cognitive impairment with 1 year or more of clinical observation after amyloid β and tau positron emission tomography (PET). Median clinical follow-up after PET r"],"journal":["JAMA neurology"],"pubmed_title":["Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment."],"pmcid":["PMC9339146"],"funding_grant_id":["P30 AG066444","K01 AG053474","P01 AG036694","R00 AG061238","P01 AG003991"],"pubmed_authors":["Breitner JCS","Chhatwal JP","Pogossova G","Gervais V","Lafaille-Magnan ME","Poirier J","Spreng N","Frenette J","Laws S","Couture D","Hoge R","Montine T","Fonov V","Vogel J","Kat J","Labonte A","Gordon BA","Martins R","Mohammediyan B","Sepulcre J","Rioux P","Tullo S","Lois Gomez C","Mathieu A","Kazazian C","Gatchel J","Carrier CE","Teigner E","Yu E","Pardilla-Delgado E","Quiroz Y","Khachaturian Z","Johnson KA","Cheewakriengkrai L","Rajah N","Ferdinand F","Appleby M","Buckley R","Dadar M","Frappier J","Dickerson B","Aisen P","Anthal E","Craft S","Taddei K","Guzman-Velez E","Debacker C","Dansereau C","Soucy JP","Bedetti C","Vachon-Presseau E","Provost K","Rentz D","Saint-Fort EF","Multhaup G","Brandt J","Hobbs DA","Ozlen H","Dore V","Jutten R","El-Khoury R","Fowler C","Reynolds G","Buckley RF","Chen Y","Evans A","Duclair G","Oaoo K","Tardif C","Near J","Desautels R","Dufour M","Daoust LA","Gagliardi G","Eisenberg M","Cuello C","Barkun A","Skylar-Scott I","Theroux L","Tuwaig M","Johnson K","Farzin S","Geddes M","Faubert AM","Dauar-Tedeschi M","McSweeney M","Madjar C","Chapleau M","Courcot B","Sager M","PREVENT-AD, HABS, and AIBL Research Groups","Morris J","Remz J","Savard M","Jean G","Breitner J","Dubuc S","Sylvain E","Benzinger TLS","Meyer PO","Collins L","Pruessner J","Villemagne VL","Gordon R","Blacker D","Wan K","Giles R","Fontaine D","Kostopoulos P","Vila-Castelar C","Page V","Ituria-Medina Y","Jacobs H","Binette AP","Verfaillie S","Knopman D","Venugopalan V","Bourgeat P","Carmo L","Ma Nter LM","Maruff P","Petkova M","Rowe CC","Villeneuve S","Leoutsakos JM","Thomas R","Pascoal T","Benbouhoud F","Mayrand G","Price J","Yang HS","Rosa-Neto P","Greco C","Tam A","Pichet Binette A","Bohbot V","St-Onge F","Sperling R","Leblond-Baccichet G","Gagne G","Sperling RA","Pishnamazi M","Orban P","Tabrizi S","Lee T","Kobe T","Gauthier S","Toussaint PJ","Salaciak A","A Lie MJ","Brown B","Strikwerda-Brown C","Wang S","Amariglio RE","Miron J","Vallee I","Lepage C","Maltais JR","Ayranci GL","Bailly J","Tremblay-Mercier J","Mathotaarachchi S","Michaud D","Schultz A","Jack C","Newbold-Fox H","Ducharme S","Donovan N","Beaudry T","Bellec P","Hudon L","Nilsson N","Picard C","Vannini P","Das S","Chakravarty M","Etienne P","Ward L","Maillet D","Farrell M","Nair V","Leppert I","Schultz S","Fripp J","Prokopiou P","Dea D","Masters CL","Marshall G","Morris JC","Boutin S","Tariot P","Rainy-Smith S","Mahar L","Gonneaud J"],"additional_accession":[]},"is_claimable":false,"name":"Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment.","description":"<h4>Importance</h4>National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD).<h4>Objective</h4>To assess the clinical value of these biological criteria to identify older individuals without cognitive impairment who are at near-term risk of developing symptomatic AD.<h4>Design, setting, and participants</h4>This longitudinal cohort study used data from 4 independent population-based cohorts (PREVENT-AD, HABS, AIBL, and Knight ADRC) collected between 2003 and 2021. Participants were older adults without cognitive impairment with 1 year or more of clinical observation after amyloid β and tau positron emission tomography (PET). Median clinical follow-up after PET r","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T17:22:27.159Z","creation":"2025-04-07T04:53:03.547Z"},"accession":"S-EPMC9339146","cross_references":{"pubmed":["35907254"],"doi":["10.1001/jamaneurol.2022.2379"]}}