biostudies-literatureRobertson JMFIC NIH HHSNHLBI NIH HHSFogarty International CenterSHARE INDIA Research Foundation314-321https://www.ebi.ac.uk/biostudies/studies/S-EPMC9339451biostudies-literatureUnknown72(4)<h4>Background</h4>Consanguineous marriage (CM) has been linked to spontaneous abortion (SAB), although studies have largely been cross-sectional and likely underestimated early loss. We aimed to determine the relationships between CM and SAB in a prospective pregnancy cohort study in Telangana State, India.<h4>Methods</h4>Data from 661 participants aged 15-35 years in the Longitudinal Indian Family hEalth (LIFE) study actively followed for pregnancy and pregnancy loss were analyzed. SAB was classified as early (< 8) or late (8-22) weeks gestation. We used logistic regression to model the relationships between CM, defined by first-cousin marriage, and SAB, adjusted for maternal age.<h4>Results</h4>Women in CM were at a modestly increased risk of any (OR_adj 1.15, 95% CI 0.69, 1.9Journal of obstetrics and gynaecology of IndiaConsanguineous Marriage and Early Pregnancy Loss in Rural to Peri-Urban India.PMC9339451D43 TW 009078T32 HL083825D43 TW009078Robertson JMBasany KHaggerty CLTan XFarooq FTang GBunker CHReddy PSfalseConsanguineous Marriage and Early Pregnancy Loss in Rural to Peri-Urban India.<h4>Background</h4>Consanguineous marriage (CM) has been linked to spontaneous abortion (SAB), although studies have largely been cross-sectional and likely underestimated early loss. We aimed to determine the relationships between CM and SAB in a prospective pregnancy cohort study in Telangana State, India.<h4>Methods</h4>Data from 661 participants aged 15-35 years in the Longitudinal Indian Family hEalth (LIFE) study actively followed for pregnancy and pregnancy loss were analyzed. SAB was classified as early (< 8) or late (8-22) weeks gestation. We used logistic regression to model the relationships between CM, defined by first-cousin marriage, and SAB, adjusted for maternal age.<h4>Results</h4>Women in CM were at a modestly increased risk of any (OR_adj 1.15, 95% CI 0.69, 1.92022-01-01T00:00:00Z2022 Aug2025-04-04T20:07:02.618Z2025-04-04T20:07:02.618ZS-EPMC93394513592350810.1007/s13224-021-01498-7