biostudies-literatureWang ZNCATS NIH HHSNIDDK NIH HHSNIAID NIH HHSNIMH NIH HHSNHLBI NIH HHSNIMHD NIH HHSNCI NIH HHS1081-1093https://www.ebi.ac.uk/biostudies/studies/S-EPMC9339474biostudies-literatureUnknown42(8)<h4>Background</h4>Alterations in gut microbiota and blood metabolomic profiles have been implicated in HIV infection and cardiovascular disease. However, it remains unclear whether alterations in gut microbiota may contribute to disrupted host blood metabolomic profiles in relation to atherosclerosis, especially in the context of HIV infection.<h4>Methods</h4>We analyzed cross-sectional associations between gut microbiota features and carotid artery plaque in 361 women with or at high risk of HIV (67% HIV+), and further integrated plaque-associated microbial features with plasma lipidomic/metabolomic profiles. Furthermore, in 737 women and men, we examined prospective associations of baseline gut bacteria-associated lipidomic and metabolomic profiles with incident carotid artery plaque ovArteriosclerosis, thrombosis, and vascular biologyGut Microbiota, Plasma Metabolomic Profiles, and Carotid Artery Atherosclerosis in HIV Infection.PMC9339474P30 AI050410K01 HL129892UL1 TR001881U01 AI035004U01 HL146205U01 HL146204U01 HL146203U01 HL146208P30 AI124414U01 HL146242R01 MD011389U01 HL146241U01 HL146240P30 CA013330U01 HL146202U01 HL146245U01 HL146201R01 HL140976R01 HL126543P30 MH116867P30 DK040561P30 AI073961P30 AI027767UL1 TR003098R01 HL132794R01 HL095140U01 AI031834UL1 TR000004P30 AI050409U01 HL146333U01 HL146194U01 HL146193U01 HL146192R01 HL083760Malvestutto CWolinsky SMClish CBAouizerat BGolub ETQi QXing JSharma AAnastos KWang TPeters BAPost WSBudoff MWang ZKassaye SBurk RDWeber KUsyk MLazar JLanday ALFrench AGustafson DHanna DBHodis HNHaberlen SKaplan RCfalseGut Microbiota, Plasma Metabolomic Profiles, and Carotid Artery Atherosclerosis in HIV Infection.<h4>Background</h4>Alterations in gut microbiota and blood metabolomic profiles have been implicated in HIV infection and cardiovascular disease. However, it remains unclear whether alterations in gut microbiota may contribute to disrupted host blood metabolomic profiles in relation to atherosclerosis, especially in the context of HIV infection.<h4>Methods</h4>We analyzed cross-sectional associations between gut microbiota features and carotid artery plaque in 361 women with or at high risk of HIV (67% HIV+), and further integrated plaque-associated microbial features with plasma lipidomic/metabolomic profiles. Furthermore, in 737 women and men, we examined prospective associations of baseline gut bacteria-associated lipidomic and metabolomic profiles with incident carotid artery plaque ov2022-01-01T00:00:00Z2022 Aug2025-04-04T20:07:33.08Z2025-04-04T20:07:33.08ZS-EPMC93394743567818710.1161/ATVBAHA.121.31727610.1161/atvbaha.121.317276