{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hayes-Larson E"],"funding":["NIA NIH HHS"],"pagination":["2209-2217"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9339583"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(11)"],"pubmed_abstract":["<h4>Introduction</h4>Most dementia studies are not population-representative; statistical tools can be applied to samples to obtain critically-needed population-representative estimates, but are not yet widely used.<h4>Methods</h4>We pooled data from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study and the California Behavioral Risk Factor Surveillance System (CA-BRFSS), a population-representative study. Using weights accounting for sociodemographic/health differences between KHANDLE and CA-BRFSS, we estimated cognitive impairment prevalence and age- and sex-adjusted racial/ethnic inequalities in California adults 65+ without prior dementia diagnosis.<h4>Results</h4>After weighting KHANDLE, the estimated cognitive impairment prevalence in California was 20.3% (95% con"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Accounting for lack of representation in dementia research: Generalizing KHANDLE study findings on the prevalence of cognitive impairment to the California older population."],"pmcid":["PMC9339583"],"funding_grant_id":["R01 AG052132","RF1 AG052132","R00 AG053410","R01 AG067199","R01 AG066132","P30 AG072972","R56 AG069126","P30 AG010129"],"pubmed_authors":["Mayeda ER","Seamans MJ","Mobley TM","Whitmer RA","Mungas D","DeCarli C","Gilsanz P","Glymour MM","Hayes-Larson E"],"additional_accession":[]},"is_claimable":false,"name":"Accounting for lack of representation in dementia research: Generalizing KHANDLE study findings on the prevalence of cognitive impairment to the California older population.","description":"<h4>Introduction</h4>Most dementia studies are not population-representative; statistical tools can be applied to samples to obtain critically-needed population-representative estimates, but are not yet widely used.<h4>Methods</h4>We pooled data from the Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) study and the California Behavioral Risk Factor Surveillance System (CA-BRFSS), a population-representative study. Using weights accounting for sociodemographic/health differences between KHANDLE and CA-BRFSS, we estimated cognitive impairment prevalence and age- and sex-adjusted racial/ethnic inequalities in California adults 65+ without prior dementia diagnosis.<h4>Results</h4>After weighting KHANDLE, the estimated cognitive impairment prevalence in California was 20.3% (95% con","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-06-01T04:21:51.388Z","creation":"2025-06-01T04:21:51.388Z"},"accession":"S-EPMC9339583","cross_references":{"pubmed":["35102726"],"doi":["10.1002/alz.12522"]}}