{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(2)"],"submitter":["Promratpan W"],"pubmed_abstract":["<b><i>Introduction:</i></b> Percutaneous mitral commissurotomy (PTMC) and mitral valve replacement (MVR) are treatments of choice for severe rheumatic mitral stenosis (MS). Data regarding the long-term outcomes of patients who underwent PTMC and MVR are limited. <b><i>Methods:</i></b> A retrospective cohort study was conducted to evaluate the long-term outcomes of patients with severe rheumatic MS who underwent PTMC or MVR between 2010 to 2020. The primary outcome comprised of all-cause death, stroke or systemic embolism, heart failure hospitalization and re-intervention. Cox regression was used to investigate predictors of the primary outcome. <b><i>Results:</i></b> 264 patients were included in analysis, 164 patients (62.1%) in PTMC group and 100 patients in MVR group (37.9%). The majority were females (80.7%) and had atrial fibrillation (68.6%). The mean age was 49.52 (SD: 13.03) years old. MVR group had more age and AF, higher Wilkins' score with smaller MVA. Primary outcome occurred significantly higher in PTMC group (37.2% vs 22%, <i>P</i>=0.002), as well as, re-intervention (18.3% vs 0%, <i>P</i><0.001). However, all-cause mortality, stroke or systemic embolism and heart failure hospitalization were not significantly different. In multivariate Cox regression analysis, PTMC (HR 1.94; 95%CI 1.14, 3.32; <i>P</i>=0.015), older age (HR 1.03; 95%CI 1.01, 1.06; <i>P</i>=0.009) and SPAP > 50 mmHg (HR 2.99; 95%CI 1.01, 8.84; <i>P</i>=0.047) were the only predictors of primary outcome. <b><i>Conclusion:</i></b> Primary outcome occurred in PTMC group more than MVR group which was driven by re-intervention. However, all-cause mortality, stroke or systemic embolism and heart failure hospitalization were not significantly different."],"journal":["Journal of cardiovascular and thoracic research"],"pagination":["101-107"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9339733"],"repository":["biostudies-literature"],"pubmed_title":["Long-term outcomes of severe rheumatic mitral stenosis after undergoing percutaneous mitral commissurotomy and mitral valve replacement: A 10-year experience."],"pmcid":["PMC9339733"],"pubmed_authors":["Theerasuwipakorn N","Lertsuwunseri V","Srimahachota S","Promratpan W"],"additional_accession":[]},"is_claimable":false,"name":"Long-term outcomes of severe rheumatic mitral stenosis after undergoing percutaneous mitral commissurotomy and mitral valve replacement: A 10-year experience.","description":"<b><i>Introduction:</i></b> Percutaneous mitral commissurotomy (PTMC) and mitral valve replacement (MVR) are treatments of choice for severe rheumatic mitral stenosis (MS). Data regarding the long-term outcomes of patients who underwent PTMC and MVR are limited. <b><i>Methods:</i></b> A retrospective cohort study was conducted to evaluate the long-term outcomes of patients with severe rheumatic MS who underwent PTMC or MVR between 2010 to 2020. The primary outcome comprised of all-cause death, stroke or systemic embolism, heart failure hospitalization and re-intervention. Cox regression was used to investigate predictors of the primary outcome. <b><i>Results:</i></b> 264 patients were included in analysis, 164 patients (62.1%) in PTMC group and 100 patients in MVR group (37.9%). The majority were females (80.7%) and had atrial fibrillation (68.6%). The mean age was 49.52 (SD: 13.03) years old. MVR group had more age and AF, higher Wilkins' score with smaller MVA. Primary outcome occurred significantly higher in PTMC group (37.2% vs 22%, <i>P</i>=0.002), as well as, re-intervention (18.3% vs 0%, <i>P</i><0.001). However, all-cause mortality, stroke or systemic embolism and heart failure hospitalization were not significantly different. In multivariate Cox regression analysis, PTMC (HR 1.94; 95%CI 1.14, 3.32; <i>P</i>=0.015), older age (HR 1.03; 95%CI 1.01, 1.06; <i>P</i>=0.009) and SPAP > 50 mmHg (HR 2.99; 95%CI 1.01, 8.84; <i>P</i>=0.047) were the only predictors of primary outcome. <b><i>Conclusion:</i></b> Primary outcome occurred in PTMC group more than MVR group which was driven by re-intervention. However, all-cause mortality, stroke or systemic embolism and heart failure hospitalization were not significantly different.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T18:08:53.535Z","creation":"2025-02-19T02:26:58.665Z"},"accession":"S-EPMC9339733","cross_references":{"pubmed":["35935386"],"doi":["10.34172/jcvtr.2022.16"]}}