{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang X"],"funding":["NIDDK NIH HHS","American Diabetes Association","National Institutes of Health"],"pagination":["dev200432"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9340549"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["149(13)"],"pubmed_abstract":["Pancreatic and duodenal homeobox 1 (PDX1) is crucial for pancreas organogenesis, yet the dynamic changes in PDX1 binding in human or mouse developing pancreas have not been examined. To address this knowledge gap, we performed PDX1 ChIP-seq and single-cell RNA-seq using fetal human pancreata. We integrated our datasets with published datasets and revealed the dynamics of PDX1 binding and potential cell lineage-specific PDX1-bound genes in the pancreas from fetal to adult stages. We identified a core set of developmentally conserved PDX1-bound genes that reveal the broad multifaceted role of PDX1 in pancreas development. Despite the well-known dramatic changes in PDX1 function and expression, we found that PDX1-bound genes are largely conserved from embryonic to adult stages. This points to"],"journal":["Development (Cambridge, England)"],"pubmed_title":["A PDX1 cistrome and single-cell transcriptome resource of the developing pancreas."],"pmcid":["PMC9340549"],"funding_grant_id":["R01DK121175","P30 DK019525","F32-DK-089747","R01 DK105689","R01DK105689","1-16-JDF086","R01 DK121175","F32 DK089747"],"pubmed_authors":["Yang X","Yang J","Rice G","Yu R","Li C","Stoffers DA","Raum JC","Kim J","Stanescu DE","Won KJ"],"additional_accession":[]},"is_claimable":false,"name":"A PDX1 cistrome and single-cell transcriptome resource of the developing pancreas.","description":"Pancreatic and duodenal homeobox 1 (PDX1) is crucial for pancreas organogenesis, yet the dynamic changes in PDX1 binding in human or mouse developing pancreas have not been examined. To address this knowledge gap, we performed PDX1 ChIP-seq and single-cell RNA-seq using fetal human pancreata. We integrated our datasets with published datasets and revealed the dynamics of PDX1 binding and potential cell lineage-specific PDX1-bound genes in the pancreas from fetal to adult stages. We identified a core set of developmentally conserved PDX1-bound genes that reveal the broad multifaceted role of PDX1 in pancreas development. Despite the well-known dramatic changes in PDX1 function and expression, we found that PDX1-bound genes are largely conserved from embryonic to adult stages. This points to","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-05-09T13:59:38.95Z","creation":"2025-04-04T20:28:29.923Z"},"accession":"S-EPMC9340549","cross_references":{"pubmed":["35708349"],"doi":["10.1242/dev.200432"]}}