{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Granata LE"],"funding":["NIMH NIH HHS","National Institute of Mental Health"],"pagination":["e22260"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9340574"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["64(3)"],"pubmed_abstract":["Early life adversity (ELA) increases risk for psychopathologies that often manifest during adolescence and involve disrupted social functioning. ELA affects development of the prefrontal cortex (PFC), which plays a role in social behavior. PFC oxytocin and vasopressin are important regulators of, first, mother-infant attachment, and, later, social behavior, and are implicated in psychiatric disorders. Here, we tested whether infant social communication is predictive of PFC development and adolescent social behavior. We used the limited bedding (LB) ELA model in rats during postnatal days (P)2-14, and measured isolation-induced ultrasonic vocalizations (USVs) at P10 to characterize differences in an early social response. Rats were tested for dyadic social interaction in adolescence (P34). "],"journal":["Developmental psychobiology"],"pubmed_title":["Infant ultrasonic vocalizations predict adolescent social behavior in rats: Effects of early life adversity."],"pmcid":["PMC9340574"],"funding_grant_id":["R01MH107556","R01 MH107556"],"pubmed_authors":["Brenhouse HC","Hirsch JL","Granata LE","Valentine A"],"additional_accession":[]},"is_claimable":false,"name":"Infant ultrasonic vocalizations predict adolescent social behavior in rats: Effects of early life adversity.","description":"Early life adversity (ELA) increases risk for psychopathologies that often manifest during adolescence and involve disrupted social functioning. ELA affects development of the prefrontal cortex (PFC), which plays a role in social behavior. PFC oxytocin and vasopressin are important regulators of, first, mother-infant attachment, and, later, social behavior, and are implicated in psychiatric disorders. Here, we tested whether infant social communication is predictive of PFC development and adolescent social behavior. We used the limited bedding (LB) ELA model in rats during postnatal days (P)2-14, and measured isolation-induced ultrasonic vocalizations (USVs) at P10 to characterize differences in an early social response. Rats were tested for dyadic social interaction in adolescence (P34). ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T21:43:53.897Z","creation":"2025-04-04T21:43:53.897Z"},"accession":"S-EPMC9340574","cross_references":{"pubmed":["35312059"],"doi":["10.1002/dev.22260"]}}